ZNRF3 Antibodies

AND ZNRF3 ELISA kits, ZNRF3 Proteins

Many biological assays use antibodies to detect ZNRF3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ZNRF3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ZNRF3 antibodies...

We validate the specificity of these antibodies to ZNRF3 by testing them on tissues known to express ZNRF3 positively and negatively. Browse below to find the ZNRF3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for ZNRF3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the ZNRF3 Western Blot Guide

ZNRF3 Infographic by Boster Bio

All ZNRF3 Products

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Product

Figures

Specificity

Applications

Price

Anti-ZNRF3 Antibody Picoband®

Western blot analysis of ZNRF3 using anti-ZNRF3 antibody (A02974-1)

IF analysis of ZNRF3 using anti-ZNRF3 antibody (A02974-1)

Flow Cytometry analysis of PC-3 cells using anti-ZNRF3 antibody (A02974-1)

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A02974-1
100 μg/vial

ZNRF3 (NM_032173) Human Over-expression Lysate

Human

$960
Cat # LS084133
20 µg, 100 µg

ZNRF3 Overview

Facts about E3 ubiquitin-protein ligase ZNRF3.

ZNRF3 3D structure. Source: alphafold

E3 ubiquitin-protein ligase ZNRF3 (ZNRF3)

E3 ubiquitin-protein ligase that functions as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway.

Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. .

Gene Information

Human
Gene Name:	ZNRF3
Uniprot:	Q9ULT6
Entrez:	84133

Family

Belongs to:

ZNRF3 family

Alternative Names

E3 ubiquitin-protein ligase ZNRF3

Molecular Weight

Mass (kDA):
100.574 kDA

Genomic Context


Human

Location:	22q12.1
Sequence:	22; NC_000022.11 (28800657..29057488)

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Interacting Proteins

FZD6
LGR4
LRP6
RSPO1

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZNRF3

References

PMID: 22575959 by Hao H.X., et al. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.

PMID: 29769720 by Szenker-Ravi E., et al. RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6.