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- Table of Contents
Facts about Zona pellucida sperm-binding protein 3.
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Human | |
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Gene Name: | ZP3 |
Uniprot: | P21754 |
Entrez: | 7784 |
Belongs to: |
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ZP domain family |
zona pellucida glycoprotein 3 (sperm receptor)
Mass (kDA):
47.018 kDA
Human | |
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Location: | 7q11.23 |
Sequence: | 7; NC_000007.14 (76397522..76442069) |
Oocytes.
[Processed zona pellucida sperm-binding protein 3]: Secreted, extracellular space, extracellular matrix. Located in oocyte zona pellucida.; Cell membrane; Single-pass type I membrane protein.
If you're looking for antibodies for Zona pelucida 3 (ZP3), you've come to the right place. Boster Bio provides high-affinity primary antibodies with excellent performance and validated against GnRH, a closely related protein in the body. Boster has high-affinity primary antibodies available for a variety of applications including immunohistochemistry, Western Blotting, and ELISA.
The production of tag-free recombinant fusion protein encompassing the promiscuous T cell epitope of tetanus toxoid and dog zona pellucida glycoprotein-3 is a promising approach for feral cat population control. A study with rabbits revealed that antibodies against fZP (and pZP) were not effective in inhibiting in vitro fertilisation and sperm binding. However, antibodies to the fZP prevented in vitro fertilization and sperm-binding in cats.
The extracellular shell that surrounds an oocyte is called the human zona. It is vital for fertilization and oocyte development and serves as a target for immunocontraception. It is also called vitelline in non-mammals. It plays a crucial role in cross-breeding.
This multilayer glycoproteinspherical shell plays a crucial role in fertilization. The beginning of fertilization can be traced back to the interaction between spermatozoas and zona pellucida. Although it is assumed that the TP is purely elastic, it also contains dissipative powers. Spermatozoa that exhibit increased motility and repulsion to oocytes cannot penetrate this impenetrable barrier.
The ZP3 gene encodes a four hundred twenty-four amino acid long protein. It also contains a 22 aa-long signal peptide. It also contains an ortholog in the mouse genomic that encodes a pseudogene. The mouse ZP3 gene and the POM121 gene in rat are related. Although they share a similar structure, the mouse ZP3 gene does not have the 'ZP Domain'.
Heterologous is when a protein that was derived from another species or organism is inserted into a host cell. This is called "xenotransplantation". ZP3's heterologous nucleic acids sequence is found in humans as well as other species. It is an important component of neurotransmission and is involved in the regulation of brain function.
GnRH (gonadotrophin-releasing hormone), also known by luliberin or gonoliberin, plays an important role in the development of immature animals' reproductive systems. It is synthesized by the hypothalamus, diffuses into the portal system, and then passes from the anterior pituitary to the hypothalamus. GnRh2 stimulates LH/FSH secretion which is crucial for both males as well as female reproductive development. The function of GnRh2 is largely conserved throughout mammals, indicating that it is a key factor in animal reproduction.
The vaccine, Heterologous Nucleic A Sequence That Encodes GnRH In Boster Bio, is made using Fusogenic Peptides. These peptides disrupt endosomes and allow nucleic acids to bypass degradation. It can also targeted to specific cell groups for intracellular uptake. Homologous DNA recombination then incorporates the nucleic- acid into the host's DNA.
The nucleic Acid Sequence can also be directly administered to the body or introduced to the cells via viral vectors. There are many ways to introduce foreign genes into cells. These include cell fusion, chromosome-mediated gene transfer, and microcell-mediated gene transfer. Alternatively, fetal livers and autologous cells can also be used for gene delivery.
Furthermore, polynucleic substances containing the sequence immunocontraceptive molecule may be used as either contraceptives or expression vectors. These expression vectors are able to express heavy chains and light chains as well as antibodies. They are specifically designed to be effective in treating a wide range of diseases. They are useful for treating sexual dysfunction and can be used as a contraceptive.
Boster Bio has developed a range of high-affinity antibodies that target the ZP3 marker for your next immunohistochemistry experiments. The antibodies have been validated in immunohistochemistry, Western blotting and ELISA. They can recognize this mark in a variety samples. This is the perfect antibody for your next immunohistochemistry study.
Immunoassays use primary antibodies as well as secondary antibodies. These techniques depend on the ability for antibodies to bind to antigens. Examples of immunoassays include Western Blotting, immunohistochemistry, and immunofluorescence, which are histopathology and proteomics tests. ELISA, which is an enzyme-linked immunesorbent assay, measures the presence of specific types of cells.
Boster Bio's primary antibody products are made from the immune system of host animals. Primarily, the antibodies are known as primary antibodies. They only bind to the targeted antibody. Because they only bind to the targeted antigen, their affinity is determined based on the non-covalent bonds they form. To test the specificity of primary antibodies, scientists immunize host animals with antigens. Once the antibody is recognized by the immune system, it is extracted from the animal’s sera and eggs.
PMID: 2385582 by Chamberlin M.E., et al. Human homolog of the mouse sperm receptor.
PMID: 1478648 by van Duin M., et al. Cloning and characterization of the human sperm receptor ligand ZP3: evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations.