Centromere/kinetochore protein zw10 homolog (ZW10)

Essential component of the mitotic checkpoint, which prevents cells from exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes on kinetochores.

Its function linked to the spindle assembly machinery is proposed to depend on its association from the mitotic RZZ complicated (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the role is proposed to depend on its association in the interphase NRZ complicated which is thought to play a role in SNARE assembly at the ER (PubMed:15029241).