Endothelial cells antibodies

and ELISA kits, proteins related to Endothelial cells.

Introduction to Endothelial cells

Endothelial cells are specialized cells that form the inner lining of blood vessels and lymphatic systems throughout the body. They play a vital role in maintaining vascular health by regulating blood flow, controlling the passage of materials and immune cells between the bloodstream and surrounding tissues, and facilitating the formation of new blood vessels through angiogenesis. Beyond their structural functions, endothelial cells are key players in inflammatory responses and the maintenance of hemostasis. In research, targeting endothelial cells with specific antibodies allows scientists to explore intricate mechanisms underlying cardiovascular diseases, cancer progression, and various inflammatory conditions. By leveraging these antibodies, researchers can gain deeper insights into endothelial cell behavior, develop targeted therapies, and advance our understanding of vascular biology, ultimately contributing to the development of innovative treatments for a wide range of health challenges.

Endothelial cells biomarkers

A01513-3

Anti-CD31/Pecam1 Antibody Picoband®, IF analysis of Pecam1 using anti-Pecam1 antibody (A01513-3).
Pecam1 was detected in a paraffin-embedded section of human norma...

PB9273

Anti-Von Willebrand Factor/VWF Antibody Picoband®, Representative images showed IHC staining of HIF-1α, VEGF, and vWF in the cerebral cortex (magnification 400 ×)
Index...

A00171

Anti-ICAM1 Antibody Picoband®, Single-cell transcriptional profiling of intracranial fusiform aneurysmal cells ( A - K ) and multi-color immunofluorescence (mIF) of smooth muscl...

Protein Name Gene Name Function
VE-cadherin CDH5 Adherens junction component critical for endothelial cell-cell adhesion and vascular integrity
PECAM-1 (CD31) PECAM1 Mediates leukocyte transmigration and involved in angiogenesis
von Willebrand factor VWF Involved in blood coagulation and endothelial function
VEGFR2 KDR Mediates responses to VEGF, promoting angiogenesis
E-selectin SELE Adhesion molecule involved in leukocyte recruitment to sites of inflammation
ICAM-1 ICAM1 Facilitates leukocyte adhesion and transmigration
VCAM-1 VCAM1 Mediates the adhesion of lymphocytes, monocytes, eosinophils to endothelial cells
eNOS NOS3 Produces nitric oxide, regulating vascular tone and blood flow
Tie2 TEK Receptor tyrosine kinase involved in angiogenesis and blood vessel maturation
Angiopoietin-1 ANGPT1 Ligand for Tie2, promoting blood vessel stability and maturation
Angiopoietin-2 ANGPT2 Antagonizes ANGPT1, involved in blood vessel remodeling
Endoglin ENG Co-receptor for TGF-beta, involved in angiogenesis
Neuropilin-1 NRP1 Co-receptor for VEGF, involved in angiogenesis and vascular permeability
Dll4 DLL4 Notch ligand involved in arterial specification and angiogenesis
EMILIN2 EMILIN2 Components of extracellular matrix, involved in vessel stabilization
PLVAP PLVAP Involved in the formation of fenestrae and diaphragms in endothelial cells
CD146 (MCAM) MCAM Adhesion molecule involved in angiogenesis and endothelial cell function
JAM-A JAM3 Junctional adhesion molecule involved in tight junction formation
S1P receptor S1PR1 Mediates sphingosine-1-phosphate signaling, regulating vascular stability
TIE1 TEK Receptor involved in angiogenesis, acting alongside Tie2

Protein Name	Gene Name	Function
VE-cadherin	CDH5	Adherens junction component critical for endothelial cell-cell adhesion and vascular integrity
PECAM-1 (CD31)	PECAM1	Mediates leukocyte transmigration and involved in angiogenesis
von Willebrand factor	VWF	Involved in blood coagulation and endothelial function
VEGFR2	KDR	Mediates responses to VEGF, promoting angiogenesis
E-selectin	SELE	Adhesion molecule involved in leukocyte recruitment to sites of inflammation
ICAM-1	ICAM1	Facilitates leukocyte adhesion and transmigration
VCAM-1	VCAM1	Mediates the adhesion of lymphocytes, monocytes, eosinophils to endothelial cells
eNOS	NOS3	Produces nitric oxide, regulating vascular tone and blood flow
Tie2	TEK	Receptor tyrosine kinase involved in angiogenesis and blood vessel maturation
Angiopoietin-1	ANGPT1	Ligand for Tie2, promoting blood vessel stability and maturation
Angiopoietin-2	ANGPT2	Antagonizes ANGPT1, involved in blood vessel remodeling
Endoglin	ENG	Co-receptor for TGF-beta, involved in angiogenesis
Neuropilin-1	NRP1	Co-receptor for VEGF, involved in angiogenesis and vascular permeability
Dll4	DLL4	Notch ligand involved in arterial specification and angiogenesis
EMILIN2	EMILIN2	Components of extracellular matrix, involved in vessel stabilization
PLVAP	PLVAP	Involved in the formation of fenestrae and diaphragms in endothelial cells
CD146 (MCAM)	MCAM	Adhesion molecule involved in angiogenesis and endothelial cell function
JAM-A	JAM3	Junctional adhesion molecule involved in tight junction formation
S1P receptor	S1PR1	Mediates sphingosine-1-phosphate signaling, regulating vascular stability
TIE1	TEK	Receptor involved in angiogenesis, acting alongside Tie2

Important Mechanisms

Angiogenesis and Vascular Remodeling

Angiogenesis, the process of new blood vessel formation from existing vasculature, is a critical sub-research area within endothelial cell studies. This mechanism is essential for various physiological processes, including wound healing, embryonic development, and the menstrual cycle. In pathological conditions, aberrant angiogenesis contributes to diseases such as cancer, diabetic retinopathy, and rheumatoid arthritis. Understanding the signaling pathways and molecular mechanisms that regulate angiogenesis enables the development of targeted therapies to either promote blood vessel growth in ischemic diseases or inhibit it in cancerous tumors. Vascular remodeling, closely linked to angiogenesis, involves the structural reorganization of blood vessels to maintain tissue homeostasis and adapt to changing physiological demands. Research in this area explores the roles of growth factors like VEGF (vascular endothelial growth factor), angiopoietins, and the extracellular matrix in orchestrating the delicate balance between vessel formation and regression. Advances in imaging techniques and molecular biology have significantly enhanced our ability to study endothelial cell behavior during angiogenesis, paving the way for novel therapeutic interventions that can modulate vascular growth and stability.

Endothelial Dysfunction and Cardiovascular Disease

Endothelial dysfunction is a pivotal sub-research area that bridges cellular biology and clinical cardiology. Endothelial cells line the interior surface of blood vessels and are integral to maintaining vascular homeostasis by regulating blood flow, vascular tone, and barrier function. Dysfunction in these cells is characterized by a reduced availability of nitric oxide, increased oxidative stress, inflammation, and impaired vasodilation. These alterations are strongly associated with the pathogenesis of various cardiovascular diseases, including atherosclerosis, hypertension, and thrombosis. Investigating the molecular mechanisms underlying endothelial dysfunction involves studying the impact of risk factors such as hyperlipidemia, diabetes, smoking, and hypertension on endothelial cell health. Research focuses on identifying biomarkers for early detection, understanding the role of endothelial progenitor cells in vascular repair, and developing therapeutic strategies to restore endothelial function. Interventions may include lifestyle modifications, pharmacological agents that enhance nitric oxide bioavailability, antioxidant therapies, and novel drug delivery systems targeting endothelial cells. By elucidating the complexities of endothelial dysfunction, this research area aims to prevent and mitigate the progression of cardiovascular diseases, ultimately improving patient outcomes and reducing the burden of heart-related illnesses worldwide.