E-selectin Antibodies

E-selectin (SELE)

Cell-surface glycoprotein having a part in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1.

May have a role in capillary morphogenesis. .

Gene Information

Human
Gene Name:	SELE
Uniprot:	P16581
Entrez:	6401

Family

Belongs to:
selectin/LECAM family

Alternative Names

CD62 antigen-like family member E; CD62E antigen; CD62E; ELAM; ELAM1; ELAM-1; ELAM1E-selectin; endothelial adhesion molecule 1; Endothelial leukocyte adhesion molecule 1; ESEL; E-Selectin; LECAM2; leukocyte endothelial cell adhesion molecule 2; Leukocyte-endothelial cell adhesion molecule 2; SELE; selectin E

Molecular Weight

Mass (kDA):
66.655 kDA

Genomic Context

Human
Location:	1q24.2
Sequence:	1; NC_000001.11 (169722640..169734079, complement)

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

• Tissue Adhesions
• Inflammation
• Cardiovascular Diseases
• Atherosclerosis
• Tumor Angiogenesis
• Malignant Neoplasms
• Inflammatory Response
• Hypertensive Disease
• Diabetes Mellitus
• Diabetes Mellitus, Non-insulin-dependent
• Neoplasm Metastasis
• Coronary Artery Disease

• Obesity
• 5,10-methylenetetrahydrofolate Reductase Deficiency
• Von Willebrand Disease
• Neoplasms
• Infarction
• Insulin Resistance
• Myocardial Infarction

Pathways

• Cell Adhesion
• Pathogenesis
• Angiogenesis
• Inflammatory Response
• Cell Activation
• Immune Response
• Endothelial Cell Activation
• Aging
• Platelet Aggregation
• Fibrinolysis
• Wound Healing
• Neutrophil Activation
• Coagulation

• Tissue Remodeling
• Secretion
• Transport
• Reproductive Process
• Proteolysis
• Neutrophil Extravasation
• Platelet Activation

PTMs

• Cleavage
• Phosphorylation
• Nitration

• Glycosylation
• Acetylation
• Oxidation

• Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SELE

Best Uses of the SELE Marker

The SELE marker is a breakthrough technology that identifies specific cell adhesion proteins, a large group of transmembrane proteins. This technology offers many benefits in terms of its versatility, which allows scientists to publish results for specific species, applications, or special samples. Additionally scientists can earn product credits for their work. This technology is broadly applicable to scientists worldwide. This article discusses the benefits of using the SELE marker to determine cell adhesion molecules.

Cell adhesion molecules (CAMs), a large collection of transmembrane protein are a significant family.

CAMs are a class of molecules that act as adhesion protein between cells. They regulate a myriad of processes such as cell adhesion, leukocyte migration. One of these processes is intravascular and transendothelial. These two types of migration involve intercellular adhesion molecules forming and reorganization in the EC cytoskeleton. In cellular signals, such as the phosphatidylinositol-4,5-bisphosphate (PIP) encourage leukocyte recruitment. A complex called the ezrin-radixin-moesin (ERAM) regulates these processes.

There are a variety of protein structures found in CAMs. Some bind to extracellular molecules, while others bind to adjacent membranes to spread laterally. Adhesion molecules, which are responsible for cell adhesion are made up of many subunits. Some of them may collaborate laterally to create molecular complexes , also known as adhesion junctions. Different mechanisms regulate cell adhesion using CAMs.

CAMs play a crucial part in epithelial morphogenesis which is the patterning and compartment definition of cells. The epithelia's expression of CAMs determines the morphogenetic cell behavior. These interactions at cell-cell borders result in changes to the function of tissues and their shape. Differential adhesion is a concept that cells in close proximity are more likely to bond with each other. This is how CAM-driven epithelial patterns are explained.

CAMs regulate the protein synthesis machinery within the cell. Integrins' binding to extracellular matrix-coated beads causes the recruitment of mRNA as well as ribosomes. This suggests that CAMs control the expression of proteins. Changes in the CAMs can affect different proteins. For example, NCAM deficient mice show decreased levels of membrane-cytoskeleton linker protein spectrin. NCAMs are exaggerated, which increases the amount of spectrin in the body.

There are a variety of CAMs. Differential adhesion permits two kinds of cells to adhere to each other. In homotypic compartments, cells stick preferentially to one another which results in the formation of a homotypic compartment. In heterotypic compartments, CAMs influence the change in cell shape and cell formation.

The SELE Marker has many benefits

Marker assisted backcrossing has many advantages over traditional breeding. While the initial cost of backcrossing assisted by marker is higher than conventional breeding, the time savings will allow for faster variety release which could result in more profits in the long term. Here are some of these advantages. These benefits are crucial in determining the best breeding strategy for you. These benefits are described in detail in this article.

Historical background

The DHR offers an application for a historical marker in order to commemorate an individual, place, event, institution, or other entity. To be eligible the applicant must have significant historical significance that goes beyond a regional or local level. For instance, it could be appropriate to build an historical marker for the Shenandoah Valley Northern Virginia, or Tidewater. The application includes detailed instructions on how you can apply for the marker.