Angiopoietin-2 (ANGPT2)

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 from the absence of ANGPT1.

In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts can induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.