Troubleshooting guides

Troubleshooting guides

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handbooks for IHC, Western
blot and ELISA for FREE.

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Glutamine Metabolism Pathway

As the most abundant free amino acid in the plasma, glutamine participates in a variety of biochemical processes, such as protein and lipid synthesis, cellular energy production, and nitrogen and carbon donation.

Glutamine metabolism occurs in proliferating cells, particularly cancer cells. The process begins with glutamine entering the cell through the amino acid transporter ASCT2/SLC1A5. In the mitochondria, glutamine undergoes glutaminolysis, which includes reaction steps from the citrate cycle and the malate-aspartate shuttle.

Through glutamine metabolism, glutamine serves as a significant energy source for cancer cells and stimulates tumor growth. As a result, scientists have been investigating how the pathway can be targeted to treat cancer.

Click below to view & download the glutamine metabolism pathway.

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