Anti-a-Synuclein (Ab-133) SNCA Antibody

alpha-Synuclein antibody

Boster Bio Anti-a-Synuclein (Ab-133) SNCA Antibody (Catalog # A00215-2). Tested in WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: A00215-2
Size: 100 µl
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IF, WB

Product Name

Anti-a-Synuclein (Ab-133) SNCA Antibody

View all alpha-Synuclein Antibodies

SKU/Catalog Number

A00215-2

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-a-Synuclein (Ab-133) SNCA Antibody (Catalog # A00215-2). Tested in WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-a-Synuclein (Ab-133) SNCA Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00215-2)

Host

Rabbit

Contents

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Peptide sequence around aa. 131~135 (E-G-Y-Q-D) derived from Human a-Synuclein.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A00215-2 is reactive to SNCA in Human, Mouse, Rat

Applications

A00215-2 is guaranteed for IF, WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

14.46kDa

Background of alpha-Synuclein

May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

Kozikowski AP, et al. (2006)ChemMedChem. 1(2):256-66.
Jakowec MW,et al.(2001)Dev Neurosci.23(2):91-9.
El-Agnaf OM,et al.(1998)FEBS Lett. 440(1-2):67-70.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Predicted MW: 18kd
Western blotting: 1:500~1:1000
Immunofluorescence: 1:100~1:200

Validation Images & Assay Conditions

Gene/Protein Information For SNCA (Source: Uniprot.org, NCBI)

Gene Name

SNCA

Full Name

Alpha-synuclein

Weight

14.46kDa

Superfamily

synuclein family

Alternative Names

alpha-Synuclein; Lewy body) 4; MGC110988; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; non-A4 component of amyloid; PARK1; PARK4; SNCA; synuclein, alpha (non A4 component of amyloid precursor); Synuclein-alpha SNCA NACP, PARK1, PARK4, PD1 synuclein alpha alpha-synuclein|I+/--synuclein|non A-beta component of AD amyloid|synuclein alpha-140|synuclein, alpha (non A4 component of amyloid precursor)|truncated alpha synuclein

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on SNCA, check out the SNCA Infographic

SNCA infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for SNCA: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A00215-2

100ul

$360

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