Anti-Angiopoietin 2/ANGPT2 Antibody

Angiopoietin-2 antibody

Boster Bio Anti-Angiopoietin 2/ANGPT2 Antibody catalog # RP1037. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat. Cited in 3 publication(s).

Product Info Summary

SKU: RP1037
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IHC

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Product Name

Anti-Angiopoietin 2/ANGPT2 Antibody

View all Angiopoietin-2 Antibodies

SKU/Catalog Number

RP1037

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Angiopoietin 2/ANGPT2 Antibody catalog # RP1037. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Angiopoietin 2/ANGPT2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # RP1037)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

E.coli-derived human Angiopoietin 2 recombinant protein (Position: Y19-N348). Human Angiopoietin 2 shares 84% and 85% amino acid (aa) sequences identity with mouse and rat Angiopoietin 2, respectively.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

RP1037 is reactive to ANGPT2 in Human, Mouse, Rat

Applications

RP1037 is guaranteed for IHC Boster Guarantee

Observed Molecular Weight

125 kDa

Calculated molecular weight

56.919kDa

Background of Angiopoietin-2

ANGPT2, also known as ANG2 or Angiopoietin 2, is a protein that in humans is encoded by the ANGPT2 gene. It is mapped to 8p23.1. ANGPT2 is a naturally occurring antagonist of ANG1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation during vasculogenesis. The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. ANGPT2 was significantly increased in plasma and alveolar edema fluid in adults with acute lung injury compared to controls or patients with hydrostatic pulmonary edema, tracheal. ANGPT2 was also significantly increased in neonates with respiratory distress syndrome who developed bronchopulmonary edema. It is also a mediator of epithelial necrosis with an important role in hyperoxic acute lung injury and pulmonary edema.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat

Validation Images & Assay Conditions

Gene/Protein Information For ANGPT2 (Source: Uniprot.org, NCBI)

Gene Name

ANGPT2

Full Name

Angiopoietin-2

Weight

56.919kDa

Alternative Names

AGPT2; ANG2; ANG-2; angiopoietin 2; Angiopoietin-2; angiopoietin-2a; angiopoietin-2B; angiopoitin 2; ANGPT2; Tie2-ligand ANGPT2 AGPT2, ANG2 angiopoietin 2 angiopoietin-2|Tie2-ligand|angiopoietin-2B|angiopoietin-2a

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on ANGPT2, check out the ANGPT2 Infographic

ANGPT2 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for ANGPT2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

RP1037 has been cited in 3 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Benefical Therapeutic Effect of Chinese Herbal Xinji'erkang Formula on Hypertension-Induced Renal Injury in the 2-Kidney-1-Clip Hypertensive Rats

Li C, Fan J, Song X, Zhang B, Chen Y, Li C, Mi K, Ma H, Song Y, Tao X, Li G. Plos One. 2013 Sep 11;8(9):E75388. Doi: 10.1371/Journal.Pone.0075388. Ecollection 2013. Expression Of Angiopoietin-2 And Vascular Endothelial Growth Factor Receptor-3 Cor...

Bai X, Li X, Tian J, Zhou Z. Plos One. 2014 Apr 23;9(4):E96117. Doi: 10.1371/Journal.Pone.0096117. Ecollection 2014. Antiangiogenic Treatment Diminishes Renal Injury And Dysfunction Via Regulation Of Local Akt In Early Experimental Diabetes.

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1 Customer Q&As for Anti-Angiopoietin 2/ANGPT2 Antibody

Question

We are currently using anti-Angiopoietin 2/ANGPT2 antibody RP1037 for rat tissue, and we are well pleased with the IHC results. The species of reactivity given in the datasheet says human, mouse, rat. Is it possible that the antibody can work on dog tissues as well?

K. Evans

Verified customer

Asked: 2013-02-27

Answer

The anti-Angiopoietin 2/ANGPT2 antibody (RP1037) has not been validated for cross reactivity specifically with dog tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in dog you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2013-02-27

Order DetailsPrice
RP1037

100μg

$370
RP1037-10ug

10μg sample (liquid)

$99
RP1037-Biotin

100 μg Biotin conjugated

$570
RP1037-Cy3

100 μg Cy3 conjugated

$570
RP1037-Dylight488

100 μg Dylight488 conjugated

$570
RP1037-Dylight550

100 μg Dylight550 conjugated

$570
RP1037-Dylight594

100 μg Dylight594 conjugated

$570
RP1037-FITC

100 μg FITC conjugated

$570
RP1037-HRP

100 μg HRP conjugated

$570
RP1037-APC

100 μg APC conjugated

$670
RP1037-PE

100 μg PE conjugated

$670
RP1037-carrier-free

Carrier Free

$370

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Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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