Rabbit IgG polyclonal antibody for Angiotensinogen(AGT) detection. Tested with WB in Mouse;Rat. Cited in 1 publication(s).
Anti-Angiotensinogen/AGT Antibody Info At A Glance
|Product Name||Anti-Angiotensinogen/AGT Antibody
See all Agt primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for Angiotensinogen/AGT detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Mouse. Angiotensinogen/AGT information: Molecular Weight: 51990 MW; Subcellular Localization: Secreted; Tissue Specificity: Expressed by the liver and secreted in plasma.|
|Cite This Product||Anti-Angiotensinogen/AGT Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1643)|
|Similar Products From
|Anti-Angiotensinogen/AGT Antibody may replace the following items: sc 167057|sc 167058|sc 20717|sc 374511|sc 7419|sc 80682|sc 86966|sc 86967.|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of mouse Angiotensinogen(25-36aa DRVYIHPFHLLY), identical to the related rat sequence.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For Agt (Source: Uniprot.org, NCBI)
|NCBI Gene Id||11606|
|Species Of This Entry||Mouse|
|Alternative Names||Agt|AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8); angiotensin I; angiotensin II; ANHU; SERPINA8|
|Post Tranlational Modifications||Methylation; Cleavage; Phosphorylation; Amination; Glycosylation; Demethylation; Reduction; Acetylation; Nitrosylation; Decarboxylation; Oxidation; Phosphorothioation; Deamination; Dephosphorylation; Ubiquitination; Iodination; Nitration; Deglycosylation|
|Gene Location||8 E2|8 72.81 cM, on Chromasome 8, gene sequence:|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For Agt (Source: Uniprot.org, NCBI)
|Protein Function||Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.|
|Tissue Specificity||Expressed by the liver and secreted in plasma.|
|Research Areas||Lipid and Metabolism|
|Related Diseases||Hypertensive Disease; Neoplasms; Malignant Neoplasms; Essential Hypertension; Diabetes Mellitus; Kidney Diseases; Hyperoxaluria, Primary; Hyperoxaluria; Primary Hyperoxaluria, Type I; Cardiovascular Diseases; Obesity; Cholangiocarcinoma; Diabetes Mellitus, Non-insulin-dependent; Hypertrophy; Carcinoma; Kidney Failure, Chronic; Infarction; Myocardial Infarction; Atherosclerosis; Insulin Resistance|
|Related Pathways||Dna Repair; Pathogenesis; Excretion; Localization; Secretion; Methylation; Cell Cycle; Translation; Transport; Drug Resistance; Glomerular Filtration; Mismatch Repair; Cell Proliferation; Regulation Of Blood Pressure; Dna Alkylation; Cell Killing; Aging; Immune Response; Cell Growth; Proteolysis|
|Background||AGT(ANGIOTENSINOGEN), also called SERPINA8, is an alpha-2-globulin that is produced constitutively and released into the circulation mainly by the liver. ATG is a member of the serpin family, although it is not known to inhibit other enzymes, unlike most serpins. Angiotensinogen is also known as renin substrate. The AGT gene is mapped on 1q42.2. And the human angiotensinogen gene contains 5 exons. The expression of AGT and enzymes required for its conversion to angiotensin II in human adipose tissue. Western blot analysis showed a distinct band of expected size of the angiotensinogen protein(61 kD) in isolated adipocytes. The more pronounced AGT increase in TT subjects resulted in similar plasma renin activity at a lower plasma active renin concentration, with a higher plasma renin activity/active renin ratio.|
|Scientific References||PMID: 3397061 by Clouston W.M., et al. Molecular cloning of the mouse angiotensinogen gene.|
PMID: 12829792 by Santos R.A.S., et al. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.
Our Boster Quality Guarantee for Anti-Angiotensinogen/AGT Antibody covers its use in the following applications.Western blot, 0.1-0.5μg/ml, Mouse, Rat
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: Mouse Liver Tissue Lysate
Lane 2: Rat Liver Tissue Lysate
Lane 3: Rat Cardiac Muscle Tissue Lysate
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
Other Recommended Resources
Here are featured tools and databases that you might find useful.
Total number of citations: 1
|Lan F, Yue X, Han L, Shi Z, Yang Y, Pu P, Yao Z, Kang C. Int J Oncol. 2012 Feb;40(2):519-26. Doi: 10.3892/Ijo.2011.1215. Epub 2011 Sep 28. Genome-Wide Identification Of Tcf7L2/Tcf4 Target Mirnas Reveals A Role For Mir-21 In Wnt-Driven Epithelial C...||PubMed ID 21956205|
Order Product (PA1643)
Domestically in USA and Canada, ships next business day if available in stock.
Note: sample size takes longer to process, average 5-7 days.
All Boster antibodies and ELISA kits are guaranteed to meet the specifications on the data sheet.See Details
Download troubleshooting handbooks for IHC, Western blot and ELISA for FREE.Download Free PDFs Now
Guaranteed product quality
We promise all of our products perform as described in datasheets.