Anti-Annexin A1/ANXA1 Antibody (Monoclonal, 34A33)

Product Name

Anti-Annexin A1/ANXA1 Antibody (Monoclonal, 34A33)

View all ANXA1 Antibodies

SKU/Catalog Number

M01451-4

Size

100 μl/vial

Form

Liquid

Description

Boster Bio Anti-Annexin A1/ANXA1 Antibody (Monoclonal, 34A33) catalog # M01451-4. Tested in IHC, IF applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Annexin A1/ANXA1 Antibody (Monoclonal, 34A33) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01451-4)

Host

Rabbit

Contents

Rabbit IgG in stabilizing components, phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
This antibody is supplied in a stabilized formulation.
Compatibility with conjugation reactions depends on the chemistry of the conjugation method used.
For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Clonality

Monoclonal

Clone Number

34A33

Immunogen

Recombinant protein within human Annexin A1 aa 3-98.

Reactive Species

M01451-4 is reactive to ANXA1 in Human

Calculated molecular weight

38.7 kDa

Background of ANXA1

ANXA1, also known as lipocortin I or Annexin A1, is a protein that in humans is encoded by the ANXA1 gene. It is mapped to 9q21.13. ANXA1 belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. ANXA1 protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Lower peptide concentrations possibly found in inflammatory situations elicit Ca(2+) transients without fully activating the mitogen-activated protein kinase pathway. This causes a specific inhibition of the transendothelial migration of neutrophils and a desensitization of neutrophils toward a chemoattractant challenge. These findings identified ANXA1 peptides as novel, endogenous FPR ligands and established a mechanistic basis of ANXA1-mediated antiinflammatory effects.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

M01451-4 is guaranteed for IF, IHC Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry, 1:50-200
Immunofluorescence, 1:50-200

Validation Images & Assay Conditions

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See full target information ANXA1

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