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Product Info Summary
| SKU: | A03991 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-ARC NOL3 Antibody
SKU/Catalog Number
A03991
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-ARC NOL3 Antibody (Catalog # A03991). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human.
Storage & Handling
ARC antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-ARC NOL3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03991)
Host
Rabbit
Contents
ARC Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
ARC antibody was raised against an 18 amino acid peptide near the carboxy terminus of human ARC. The immunogen is located within the last 50 amino acids of ARC.
Reactive Species
A03991 is reactive to NOL3 in Human
Observed Molecular Weight
68 kDa
Calculated molecular weight
22.6 kDa
Background of NOL3
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A03991 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ARC antibody can be used for detection of ARC by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of ARC in (H) HeLa, (K) K562, and (A) A549 whole cell lysates with ARC antibody at 1 μg/mL.
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Immunohistochemistry of ARC in human heart tissue with ARC antibody at 5 μg/mL.
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Immunohistochemistry of ARC in human skeletal muscle with ARC antibody at 5 μg/mL.
Specific Publications For Anti-ARC NOL3 Antibody (A03991)
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