Anti-ARMER ARL6IP1 Antibody

Product Name

Anti-ARMER ARL6IP1 Antibody

View all ARMER Antibodies

SKU/Catalog Number

A08487

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-ARMER ARL6IP1 Antibody (Catalog # A08487). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Storage & Handling

ARMER antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-ARMER ARL6IP1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08487)

Host

Rabbit

Contents

ARMER Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

ARMER antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human ARMER. The immunogen is located within the last 50 amino acids of ARMER.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

GLIPR1 antibody is human and mouse reactive. At least two isoforms of GLIPR1 are known to exist; this antibody will detect both isoforms. This antibody is predicted to not cross-react with other GLIPR or GLIPR-like proteins.

Reactive Species

A08487 is reactive to ARL6IP1 in Human, Mouse

Applications

A08487 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

23.363kDa

Background of ARMER

Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA. Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress. Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity, although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

ARMER antibody can be used for detection of ARMER by Western blot at 0.5 to 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2 μg/mL. For immunofluorescence start at 2 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot ana-lysis of ARMER in mouse small intestine tissue lysates with ARMER antibody at (A) 0.5

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Immunohistochemical staining of human bladder tissue using ARMER antibody at 2 μg/mL.

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Immunofluorescence of ARMER in Mouse Intestine cells with ARMER antibody at 2 μg/mL.

Gene/Protein Information For ARL6IP1 (Source: Uniprot.org, NCBI)

Alternative Names

ADP-ribosylation factor-like 6 interacting protein 1; ADP-ribosylation factor-like 6 interacting protein; AIP1; Aip-1; apoptotic regulator in the membrane of the endoplasmic reticulum; ARL-6-interacting protein 1; ARL6IPaip-1; ARMER; KIAA0069ADP-ribosylation factor-like protein 6-interacting protein 1 ARL6IP1 AIP1, ARL6IP, ARMER, SPG61 ADP ribosylation factor like GTPase 6 interacting protein 1 ADP-ribosylation factor-like protein 6-interacting protein 1|ADP-ribosylation factor GTPase 6 interacting protein 1|ADP-ribosylation factor-like 6 interacting protein 1|ARL-6-interacting protein 1|aip-1|apoptotic regulator in the membrane of the endoplasmic reticulum

For more info on ARL6IP1, check out the ARL6IP1 Infographic

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In this infographic, you will see the following information for ARL6IP1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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