Anti-Beta Arrestin 2/ARRB2 Antibody Picoband®

Product Name

Anti-Beta Arrestin 2/ARRB2 Antibody Picoband®

View all ARRB2 Antibodies

SKU/Catalog Number

PA1845
BA3767 is an alternative SKU for this antibody, used in previous lots.

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Beta Arrestin 2/ARRB2 Antibody catalog # PA1845. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Beta Arrestin 2/ARRB2 Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1845)

Host

Rabbit

Contents

Each vial contains antibody formulated with stabilizing components, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
*This antibody is supplied in a stabilized formulation. Compatibility with conjugation reactions depends on the chemistry of the conjugation method used. For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Beta Arrestin 2, different from the related rat and mouse sequences by two amino acids.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1845 is reactive to ARRB2 in Human, Mouse, Rat

Observed Molecular Weight

46 kDa

Calculated molecular weight

46.1 kDa

Background of ARRB2

ARRB2 (arrestin beta-2), also known as Beta-arrestin-2, BARR2, ARB2, DKFZp686L0365, arrestin 3, is an intracellularprotein that in humans is encoded by the ARRB2 gene. Members of arrestin/beta-arrestin protein family are though to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals, as well as having signalling roles in their own right. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Beta-arrestins were originally discovered in the context of heterotrimeric G protein-coupled receptor desensitization, but they also function in internalization and signaling of these receptors.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PA1845 is guaranteed for IHC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse

Positive Control

WB: HELA Whole Cell, Rat Skeletal Muscle Tissue
IHC: Human Intestinal Cancer Tissue, Rat Testis Tissue

Validation Images & Assay Conditions

See full target information ARRB2

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