Anti-Bone Sialoprotein/IBSP Antibody

IBSP/Sialoprotein II antibody

Boster Bio Anti-Bone Sialoprotein/IBSP Antibody catalog # PA1505. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. Cited in 3 publication(s).

Product Info Summary

SKU: PA1505
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IHC, WB

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Product Name

Anti-Bone Sialoprotein/IBSP Antibody

View all IBSP/Sialoprotein II Antibodies

SKU/Catalog Number

PA1505

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Bone Sialoprotein/IBSP Antibody catalog # PA1505. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Bone Sialoprotein/IBSP Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1505)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Bone Sialoprotein, different from the related rat and mouse sequences by three amino acids.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1505 is reactive to IBSP in Human, Mouse, Rat

Applications

PA1505 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

37 kDa

Calculated molecular weight

35.148kDa

Background of IBSP/Sialoprotein II

BSP is also known as IBSP (integrin-binding sialoprotein). The protein encoded by this gene is a major structural protein of the bone matrix. Bone sialoprotein is an acidic glycoprotein of approximately 70 kD that undergoes extensive posttranslational modifications. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. The BSP gene is mapped to 4q22.1.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse

Validation Images & Assay Conditions

Gene/Protein Information For IBSP (Source: Uniprot.org, NCBI)

Gene Name

IBSP

Full Name

Bone sialoprotein 2

Weight

35.148kDa

Alternative Names

BNSP; Bone sialoprotein 2; Bone sialoprotein; BSP 2; BSP II; BSP; BSP2; BSPII; BSP-II; Cell binding sialoprotein; IBSP; Integrin binding sialoprotein; SP II; SPII; SP-II IBSP BNSP, BSP, BSP-II, SP-II integrin binding sialoprotein bone sialoprotein 2|BSP II|bone sialoprotein II|cell-binding sialoprotein

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on IBSP, check out the IBSP Infographic

IBSP infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for IBSP: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

PA1505 has been cited in 3 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Liu B,Xu M,Guo Z,Liu J,Chu X,Jiang H.Interleukin-8 promotes prostate cancer bone metastasis through upregulation of bone sialoprotein.Oncol Lett.2019 May;17(5):4607-4613.doi:10.3892/ol.2019.10138.Epub 2019 Mar 12.PMID:30988819;PMCID:PMC6447917.
Species: Human
PA1505 usage in article: APP:WB, SAMPLE:LNCAP CELL AND DU145 CELL, DILUTION:1:500

Effect of kidney-reinforcing and marrow-beneficial Chinese medicine on bone metabolism-related factors following spinal cord injury in rats

The Osteogenic Potential of Mesoporous Bioglasses/Silk and Non-Mesoporous Bioglasses/Silk Scaffolds in Ovariectomized Rats: In vitro and In vivo Evaluation

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Order DetailsPrice
PA1505

100μg

$370
PA1505-10ug

10μg sample (liquid)

$99
PA1505-Biotin

100 μg Biotin conjugated

$570
PA1505-Cy3

100 μg Cy3 conjugated

$570
PA1505-Dylight488

100 μg Dylight488 conjugated

$570
PA1505-Dylight550

100 μg Dylight550 conjugated

$570
PA1505-Dylight594

100 μg Dylight594 conjugated

$570
PA1505-FITC

100 μg FITC conjugated

$570
PA1505-HRP

100 μg HRP conjugated

$570
PA1505-APC

100 μg APC conjugated

$670
PA1505-PE

100 μg PE conjugated

$670
PA1505-carrier-free

Carrier Free

$370

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