Anti-Bonzo/CXCR6 Antibody

Product Name

Anti-Bonzo/CXCR6 Antibody

View all CXCR6 Antibodies

SKU/Catalog Number

PA2082-1

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Bonzo/CXCR6 Antibody catalog # PA2082-1. Tested in IHC, WB applications. This antibody reacts with Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Bonzo/CXCR6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA2082-1)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of mouse Bonzo, different from the related rat sequence by two amino acids, and from the related human sequence by three amino acids

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA2082-1 is reactive to CXCR6 in Mouse, Rat

Applications

PA2082-1 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

39.28kDa

Background of CXCR6

CXCR6 (Chemokine,CXC Motif, Receptor 6), also known as STRL33, is a protein that in humans is encoded by the CXCR6 gene. By Southern blot analysis of genomic DNA and somatic cell hybrid analysis, Liao et al. (1997) mapped the single-copy STRL33 gene to chromosome 3. Matloubian et al. (2000) found that human and mouse cells expressing CXCR6 showed a strong chemotactic response to CXCL16 but not to other chemokines. The authors concluded that CXCL16 and CXCR6 probably function in interactions between dendritic cells and T cells and in regulating T-cell migration in the splenic red pulp. Kim et al. (2001) concluded that CXCR6 may be important in the trafficking of effector T cells mediating type-1 inflammation.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Rat, Mouse, By Heat
Western blot, 0.1-0.5μg/ml, Mouse, Rat

Validation Images & Assay Conditions

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Anti-CXCR6 antibody, PA2082-1, IHC(P)
IHC(P): Rat Spleen Tissue

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Anti-CXCR6 antibody, PA2082-1, Western blotting
All lanes: Anti CXCR6 (PA2082-1) at 0.5ug/ml
Lane 1: Rat Brain Tissue Lysate at 50ug
Lane 2: Rat Testis Tissue Lysate at 50ug
Lane 3: Rat Spleen Tissue Lysate at 50ug
Lane 4: Mouse Brain Tissue Lysate at 50ug
Lane 5: Mouse Testis Tissue Lysate at 50ug
Predicted bind size: 39KD
Observed bind size: 39KD

Gene/Protein Information For CXCR6 (Source: Uniprot.org, NCBI)

Alternative Names

Bonzo; BONZOG-protein coupled receptor bonzo; CD186 antigen; CD186; CDw186; chemokine (C-X-C motif) receptor 6; C-X-C chemokine receptor type 6; CXCR6; CXC-R6; CXCR-6; G protein-coupled receptor; STRL33; STRL33G-protein coupled receptor STRL33; TYMSTRCD186 CXCR6 BONZO, CD186, CDw186, STRL33, TYMSTR C-X-C motif chemokine receptor 6 C-X-C chemokine receptor type 6|G protein-coupled receptor|G-protein coupled receptor STRL33|G-protein coupled receptor bonzo|chemokine (C-X-C motif) receptor 6

For more info on CXCR6, check out the CXCR6 Infographic

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In this infographic, you will see the following information for CXCR6: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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