Anti-CD110 MPL Antibody

Thrombopoietin R/Tpo R antibody

Boster Bio Anti-CD110 MPL Antibody catalog # A00483. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: A00483
Size: 100μl
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IHC, WB

Product Name

Anti-CD110 MPL Antibody

View all Thrombopoietin R/Tpo R Antibodies

SKU/Catalog Number

A00483

Size

100μl

Form

Liquid

Description

Boster Bio Anti-CD110 MPL Antibody catalog # A00483. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-CD110 MPL Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00483)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

8F6A9; 8H5C5

Isotype

IgG

Immunogen

Synthesized peptide derived from the Internal region of human CD110.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A00483 is reactive to MPL in Human, Mouse, Rat

Applications

A00483 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

71.245kDa

Background of Thrombopoietin R/Tpo R

SKP1 is also known as S-phase kinase-associated protein 1A, Cyclin A/CDK2-associated protein p19, p19A, p19skp1, RNA polymerase II elongation factor-like protein, Organ of Corti protein 2, OCP-II protein, OCP-2, Transcription elongation factor B, and SIII. SKP1 is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, SKP1 serves as an adapter that links the F-box protein to CUL1. SKP1 interacts directly with CUL1 and F-box proteins, such as BTRC and SKP2, in the SCF complex. SKP1 also interacts with FBX29 and the cyclin A/CDK2 complex. SKP1 is part of a SCF-like complex consisting of CUL7, RBX1, SKP1 and FBXW8 and is also a component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1A, APC and TBL1X.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:500-1:2000
IHC-P, 1:100-1:300

Validation Images & Assay Conditions

Gene/Protein Information For MPL (Source: Uniprot.org, NCBI)

Gene Name

MPL

Full Name

Thrombopoietin receptor

Weight

71.245kDa

Superfamily

type I cytokine receptor family

Alternative Names

CD110 antigen; CD110; c-Mpl; MPL; MPLV; Myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; Proto-oncogene c-Mpl; Thrombopoietin R; thrombopoietin receptor; TpoR; TPO-R; TPORMPLV MPL C-MPL, CD110V, THCYT2, THPOR, TPOR, MPL MPL proto-oncogene, thrombopoietin receptor thrombopoietin receptor|TPO-R|myeloproliferative leukemia protein|myeloproliferative leukemia virus oncogene|proto-oncogene c-Mpl

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on MPL, check out the MPL Infographic

MPL infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for MPL: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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7 Customer Q&As for Anti-CD110 MPL Antibody

Question

Can you help my question with product A00483, anti-CD110 antibody. I was wondering if it would be possible to conjugate this antibody with biotin. I would need it to be without BSA or sodium azide. I am planning on using a buffer exchange of sodium azide with PBS only. Would there be problems for me to conjugate the antibody and store it in -20 degrees in small aliquots?

Verified Customer

Verified customer

Asked: 2018-12-19

Answer

We do not advise storing this antibody with PBS buffer only in -20 degrees. If you want to store it in -20 degrees it is best to add some cryoprotectant like glycerol. If you want carrier free A00483 anti-CD110 antibody, we can provide it to you in a special formula with trehalose and/or glycerol. These molecules will not interfere with conjugation chemistry and provide a good level of protection for the antibody from degradation. Please be sure to specify this in your purchase order.

Boster Scientific Support

Answered: 2018-12-19

Question

Here is the WB image, lot number and protocol we used for dorsolateral prefrontal cortex using anti-CD110 antibody A00483. Please let me know if you require anything else.

Verified Customer

Verified customer

Asked: 2018-07-05

Answer

Thank you very much for the data. Our lab team are working to resolve this as quickly as possible, and we appreciate your patience and understanding! You have provided everything we needed. Please let me know if there is anything you need in the meantime.

Boster Scientific Support

Answered: 2018-07-05

Question

Will anti-CD110 antibody A00483 work for IHC with dorsolateral prefrontal cortex?

Verified Customer

Verified customer

Asked: 2018-01-08

Answer

According to the expression profile of dorsolateral prefrontal cortex, MPL is highly expressed in dorsolateral prefrontal cortex. So, it is likely that anti-CD110 antibody A00483 will work for IHC with dorsolateral prefrontal cortex.

Boster Scientific Support

Answered: 2018-01-08

Question

I was wanting to use to test anti-CD110 antibody A00483 on human dorsolateral prefrontal cortex for research purposes, then I may be interested in using anti-CD110 antibody A00483 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?

Verified Customer

Verified customer

Asked: 2017-11-08

Answer

The products we sell, including anti-CD110 antibody A00483, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.

Boster Scientific Support

Answered: 2017-11-08

Question

Do you have a BSA free version of anti-CD110 antibody A00483 available?

Verified Customer

Verified customer

Asked: 2017-10-30

Answer

Thanks for your recent telephone inquiry. I can confirm that some lots of this anti-CD110 antibody A00483 are BSA free. For now, these lots are available and we can make a BSA free formula for you free of charge. It will take 3 extra days to prepare. If you require this antibody BSA free again in future, please do not hesitate to contact me and I will be pleased to check which lots we have in stock that are BSA free.

Boster Scientific Support

Answered: 2017-10-30

Question

I appreciate helping with my inquiry over the phone. Here are the WB image, lot number and protocol we used for dorsolateral prefrontal cortex using anti-CD110 antibody A00483. Let me know if you need anything else.

K. Dhar

Verified customer

Asked: 2015-03-30

Answer

Thanks for the data. You have provided everything we needed. Our lab team are working to resolve your inquiry as quickly as possible, and we appreciate your patience and understanding! Please let me know if there is anything you need in the meantime.

Boster Scientific Support

Answered: 2015-03-30

Question

We are currently using anti-CD110 antibody A00483 for human tissue, and we are content with the IHC results. The species of reactivity given in the datasheet says human, mouse, rat. Is it possible that the antibody can work on canine tissues as well?

M. Roberts

Verified customer

Asked: 2014-06-06

Answer

The anti-CD110 antibody (A00483) has not been validated for cross reactivity specifically with canine tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in canine you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2014-06-06

Order DetailsPrice
A00483

100uL

$399

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