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Thrombopoietin receptor Antibodies
AND MPL ELISA kits, Thrombopoietin receptor Proteins
Many biological assays use antibodies to detect Thrombopoietin receptor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Thrombopoietin receptor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Thrombopoietin receptor antibodies...
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MPL Infographic by Boster Bio
All MPL Products
Product
Figures
Specificity
Applications
Price
Mouse
ELISA
$750
Cat # EK1436
96 wells/kit, with removable strips.
Cat # EK1436
96 wells/kit, with removable strips.
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00483-1
100 μg
Cat # M00483-1
100 μg
MPL Overview
Facts about Thrombopoietin receptor.
Thrombopoietin receptor (MPL)
Receptor for thrombopoietin that functions as a key regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | MPL |
| Uniprot: | P40238 |
| Entrez: | 4352 |
Family
| Belongs to: |
|---|
| type I cytokine receptor family |
Alternative Names
CD110 antigen; CD110; c-Mpl; MPL; MPLV; Myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; Proto-oncogene c-Mpl; Thrombopoietin R; thrombopoietin receptor; TpoR; TPO-R; TPORMPLV
Molecular Weight
Mass (kDA):
71.245 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p34.2 |
| Sequence: | 1; NC_000001.11 (43336875..43354466) |
Tissue Specificity
Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cell surface.
Diseases
- Thrombocytosis
- Myeloproliferative Disease
- Neoplasms
- Leukemia
- Thrombocythemia, Essential
- Primary Myelofibrosis
- Polycythemia Vera
- Polycythemia
- Myeloid Leukemia
- Malignant Neoplasms
- Leukemia, Myelocytic, Acute
- Anemia
Interacting Proteins
- JAK2
Pathways
- Immune Response
- Pathogenesis
- Cell Proliferation
- Cell Growth
- Megakaryocyte Differentiation
- Localization
- Secretion
- Megakaryocyte Development
- Platelet Aggregation
- Hypersensitivity
- Platelet Activation
- Cell Cycle
- Cell Differentiation
PTMs
- Phosphorylation
- Glycosylation
- Cleavage
- Methylation
- Ubiquitination
- Biotinylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MPL
bosterbio.com/bosterbio-gene-info-cards/MPL
References
PMID: 1608974 by Vigon I., et al. Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily.
PMID: 8020956 by Mignotte V., et al. Structure and transcription of the human c-mpl gene (MPL).