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Product Info Summary
| SKU: | M04577 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | Flow Cytometry, ICC |
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Product info
Product Name
Anti-CD370 Purified CLEC9A Monoclonal Antibody
SKU/Catalog Number
M04577
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-CD370 Purified CLEC9A Monoclonal Antibody (Catalog# M04577). Tested in Flow Cytometry, ICC application(s). This antibody reacts with Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-CD370 Purified CLEC9A Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M04577)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
8F9
Isotype
Mouse IgG2a
Immunogen
RBL-2H3 cells expressing human CLEC9A fused to an HA epitope. The mouse monoclonal antibody 8F9 recognizes an extracellular epitope of CD370 / CLEC9A (DNGR1), a type II transmembrane protein functioning as an endocytic receptor on BDCA31+ dendritic cells and on a subset of CD14+ CD16- monocytes.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This antibody does not cross-react with Thy-1.1 alloantigen.
Reactive Species
M04577 is reactive to Clec9a in Human
Applications
M04577 is guaranteed for Flow Cytometry, ICC Boster Guarantee
Observed Molecular Weight
42 kDa
Calculated molecular weight
27.014kDa
Background of Clec9a
CD370 / CLEC9A, also known as DNGR1, is a type II transmembrane glycoprotein with extracellular C-type lectin domain and intracellular ITAM-containing domain. Its expression is restricted to BDCA3+ conventional dendritic cells and to a subset of CD14+ CD16- monocytes. CD370 serves as a receptor for ubiquitous preformed acid-labile protein associated ligands that are exposed when the cell membrane is damaged, such as on necrotic cells. Its triggering by these ligands mediates recruitment and activation of the tyrosine kinase Syk and leads to their cross-presentation to the immune system.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow cytometry: 1-4 µg/ml
Validation Images & Assay Conditions
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Protein Target Info & Infographic
Gene/Protein Information For Clec9a (Source: Uniprot.org, NCBI)
Gene Name
Clec9a
Full Name
C-type lectin domain family 9 member A
Weight
27.014kDa
Alternative Names
CD370; CLEC9a; C-type lectin domain family 9 member A; C-type lectin domain family 9, member A; DNGR1; HEEE9341; UNQ9341 Clec9a|9830005G06Rik, DNGR, DNGR-1|C-type lectin domain family 9, member a|C-type lectin domain family 9 member A|dendritic cell natural killer lectin group receptor 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Clec9a, check out the Clec9a Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Clec9a: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CD370 Purified CLEC9A Monoclonal Antibody (M04577)
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No publications found for M04577
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