Product Info Summary
SKU: | PA1715 |
---|---|
Size: | 100 μg/vial |
Reactive Species: | Human |
Host: | Rabbit |
Application: | IHC, WB |
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Product info
Product Name
Anti-CD62P/SELP Antibody
View all P-Selectin/CD62P Antibodies
SKU/Catalog Number
PA1715
Size
100 μg/vial
Form
Lyophilized
Description
Boster Bio Anti-CD62P/SELP Antibody catalog # PA1715. Tested in IHC, WB applications. This antibody reacts with Human.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-CD62P/SELP Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1715)
Host
Rabbit
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human CD62P.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins
Reactive Species
PA1715 is reactive to SELP in Human
Applications
PA1715 is guaranteed for IHC, WB Boster Guarantee
Observed Molecular Weight
140 kDa
Calculated molecular weight
90.834kDa
Background of P-Selectin/CD62P
P-Selectin, also called CD62, GRMP, GMP140 is a 140-kD adhesion molecule, expressed at the surface of activated cells, that mediates the interaction of activated endothelial cells or platelets with leukocytes. The P-Selectin gene is mapped on 1q24.2. P-selectin plays an essential role in the initial recruitment of leukocytes (white blood cells) to the site of injury during inflammation. P-selectin is also very important in the recruitment and aggregation of platelets at areas of vascular injury. In quiescent platelet, P-selectin is located on the inner wall of alpha-granules. Sorting nexin-17 interacts with the cytosolic domain of P-selectin and suggested that SNX17 may function in the intracellular trafficking of P-selectin. P-selectin expression was found to be significantly and positively correlated with carotid artery stiffness and wall thickness, and the percentage of P-selectin-positive platelets was significantly higher in patients with carotid plaque.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Reconsitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human
Validation Images & Assay Conditions
Click image to see more details
Anti-CD62P antibody, PA1715, Western blotting
All lanes: Anti CD62P (PA1715) at 0.5ug/ml
WB: PANC Whole Cell Lysate at 40ug
Predicted bind size: 91KD
Observed bind size: 140KD
Click image to see more details
Anti-CD62P antibody, PA1715, IHC(P)
IHC(P): Human Mammary Cancer Tissue
Click image to see more details
Anti-CD62P antibody, PA1715, IHC(P)
IHC(P): Human Placenta Tissue
Protein Target Info & Infographic
Gene/Protein Information For SELP (Source: Uniprot.org, NCBI)
Gene Name
SELP
Full Name
P-selectin
Weight
90.834kDa
Superfamily
selectin/LECAM family
Alternative Names
CD62P antigen; CD62P; FLJ45155; GMP140; GRMP; PADGEM; PADGEMantigen CD62); PSEL; P-Selectin; selectin P (granule membrane protein 140kDa, antigen CD62); SELP SELP CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL selectin P P-selectin|CD62 antigen-like family member P|GMP-140|granule membrane protein 140|granule membrane protein 140kDa|granulocyte membrane protein|leukocyte-endothelial cell adhesion molecule 3|platelet activation dependent granule-external membrane protein|platelet alpha-granule membrane protein|selectin P (granule membrane protein 140kDa, antigen CD62)
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SELP, check out the SELP Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SELP: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CD62P/SELP Antibody (PA1715)
Hello CJ!
PA1715 has been cited in 2 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Shu G,Lu C,Wang Z,Du Y,Xu X,Xu M,Zhao Z,Chen M,Dai Y,Weng Q,Fang S,Fan K,Liu D,Du Y,Ji J. Fucoidan-based micelles as P-selectin targeted carriers for synergistic treatment of acute kidney injury. Nanomedicine. 2020 Nov 27:102342.doi:10.1016/j.nano.2020.10
Species: Human,Mouse
PA1715 usage in article: APP:WB, SAMPLE:HUVECS, DILUTION:NA
Plasma Vitamin D Status and Its Correlation with Risk Factors of Thrombosis, P-selectin and hs-CRP Level in Patients with Venous Thromboembolism; the First Study of Iranian Population
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Customer Reviews
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Customer Q&As
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1 Customer Q&As for Anti-CD62P/SELP Antibody
Question
Do you have the IHC staining images generated by this anti-CD62P antibody for activated platelets?
Verified Customer
Verified customer
Asked: 2020-02-07
Answer
No we do not.
Boster Scientific Support
Answered: 2020-02-07