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We validate the specificity of these antibodies to P-selectin by testing them on tissues known to express SELP positively and negatively. Browse below to find the SELP antibody that suites your experiment. We have 13 of these antibodies and many publications and validation images.
If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.
Facts about P-selectin.
The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the first steps in inflammation through interaction with SELPLG.
CD62P antigen; CD62P; FLJ45155; GMP140; GRMP; PADGEM; PADGEMantigen CD62); PSEL; P-Selectin; selectin P (granule membrane protein 140kDa, antigen CD62); SELP
|Sequence:||1; NC_000001.11 (169588849..169630125, complement)|
Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
Cell membrane; Single-pass type I membrane protein.
This article will provide details about monoclonal antibodies that are anti-PECAM-1 (Endothelial Cell Marker), and anti-CD34. It also provides optimization tips and troubleshooting tips to help you get the best results from your experiments. Although there are many things that could cause problems with your experiments and experiments, proper controls can aid in eliminating them.
Boster Bio's monclonal anti-CD34 antibody utilizes the SELP marker to identify human hematopoietic stem cells. It has been extensively tested on various platforms, with positive samples as well as unpublished ones. It is highly specific and has a high affinity, making it a great instrument for the isolation and purification human HSCs. The monoclonal antibody also recognizes various cell types, which are essential for HSC differentiation.
Anti-CD31/PECAM-1, which is a highly specific anti-endothelial antibody, is available. This glycoprotein is a transmembrane that is expressed on a diverse variety of cells, including endothelial cells. This anti-endothelial cell antibody is particularly useful in identifying stem cells and the concentration of them for bone transplantation. It is highly specific for vascular endothelial cell. Moreover, it reacts with benign, normal and malignant endothelial cells. Therefore, the role of CD31 in tumor angiogenesis is crucial because high levels of CD31 expression on endothelial cells indicates the rapid growth of tumors.
The polyclonal antibody anti-CD31/PECAM-1 from Boster Bio recognizes the protein in vitro. It is a binder to CD31 intracellular immunoreceptor that carries out its adhesive properties and is associated with an endothelial marker. The polyclonal antibody is validated in clinical trials as a reliable tool to monitor the activity of endothelial cells in patients.
CD31 is an inhibitory receptor that regulates the activity of T and B cells. It is abundantly expressed on platelets and endothelial cells. It has multiple functions in the vascular biology and function of platelets. It is also vital in the regulation and migration of leukocytes along the venular walls.
The Anti-CD31/PECAM-1 monoclonal antibody from Boster Bio has been validated by IHC-P and IF. It reacts with Human, Monkey, and Rabbit tissues. It is a useful tool for animal, veterinary, and human research. It is highly sensitive and enables rapid detection of the protein targeted.
PECAM can be found in platelets, monocytes and neutrophils, as well as in a few T-cell varieties. It regulates the function of RhoA. It is therefore a good anti-apoptotic antibody. It is a very specific antibody, which is vital for cancer research.
Boster Bio optimization tips are among the most effective ways to increase the performance and efficiency of your experiments. These tips and guides will answer a variety of questions regarding your experiments, such as:
You need to pinpoint what is the root of the issue to solve it. A new component or peripheral can be the cause of the issue, as well as an error code. If the error is random, you must look into the settings on your computer to determine its cause. Try to reproduce the issue, if possible. The issue may be present at any time, or intermittently throughout the day or week.
*More publications can be found for each product on its corresponding product page