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Product Info Summary
| SKU: | A10988 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-CDIP CDIP1 Antibody
SKU/Catalog Number
A10988
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-CDIP CDIP1 Antibody (Catalog # A10988). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
CDIP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-CDIP CDIP1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10988)
Host
Rabbit
Contents
CDIP Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
CDIP antibody was raised against a 16 amino acid synthetic peptide near the center of human CDIP. The immunogen is located within amino acids 40 - 90 of CDIP.
Reactive Species
A10988 is reactive to CDIP1 in Human, Mouse
Observed Molecular Weight
68 kDa
Calculated molecular weight
21.9 kDa
Background of CDIP1
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A10988 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CDIP antibody can be used for detection of CDIP by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of CDIP in human brain lysate with CDIP antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of FNIP2 in mouse brain tissue with FNIP2 antibody at 2.5 μg/mL.
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Immunofluorescence of CDIP1 in mouse brain tissue with CDIP1 antibody at 20 μg/mL.
Specific Publications For Anti-CDIP CDIP1 Antibody (A10988)
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