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Product Info Summary
| SKU: | A08274-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Cell death regulator Aven Aven Antibody
SKU/Catalog Number
A08274-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Cell death regulator Aven Aven Antibody (Catalog # A08274-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Aven antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Cell death regulator Aven Aven Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08274-1)
Host
Rabbit
Contents
Aven Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Aven antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human Aven. The immunogen is located within the last 50 amino acids of Aven.
Reactive Species
A08274-1 is reactive to AVEN in Human, Mouse, Rat
Observed Molecular Weight
68 kDa
Calculated molecular weight
38.5 kDa
Background of AVEN
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A08274-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Aven antibody can be used for detection of Aven by Western blot at 1 μg/mL. Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Aven in Raji cell lysate with Aven antibody at 1 μg/mL in (A) the presence and (B) the absence of blocking peptide.
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Immunohistochemistry of Aven in human spleen tissue with Aven antibody at 5 μg/mL.
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Immunofluorescence of AVEN in Human Spleen cells with AVEN antibody at 20 μg/mL.
Specific Publications For Anti-Cell death regulator Aven Aven Antibody (A08274-1)
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