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Product Info Summary
| SKU: | A06387 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-CISD2 Antibody
SKU/Catalog Number
A06387
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-CISD2 Antibody (Catalog # A06387). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
CISD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-CISD2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06387)
Host
Rabbit
Contents
CISD2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2. The immunogen is located within amino acids 40 - 90 of CISD2.
Reactive Species
A06387 is reactive to CISD2 in Human, Mouse, Rat
Observed Molecular Weight
68 kDa
Calculated molecular weight
15.3 kDa
Background of CISD2
Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A06387 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of CISD2 in rat brain tissue lysate with CISD2 antibody at (A) 1 and (B) 2 μg/m
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Immunohistochemistry of CISD2 in rat brain tissue with CISD2 antibody at 2.5 μg/ml.
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Immunofluorescence of CISD2 in rat brain tissue with CISD2 antibody at 20 μg/ml.
Specific Publications For Anti-CISD2 Antibody (A06387)
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