Product Info Summary
SKU: | A03645 |
---|---|
Size: | 100ul |
Reactive Species: | Human |
Host: | Rabbit |
Application: | ELISA, WB |
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Product info
Product Name
Anti-Cleaved-PAR-4 (G48) F2RL3 Antibody
SKU/Catalog Number
A03645
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Cleaved-PAR-4 (G48) F2RL3 Antibody catalog # A03645. Tested in ELISA, WB applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Cleaved-PAR-4 (G48) F2RL3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03645)
Host
Rabbit
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human PAR-4
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A03645 is reactive to F2RL3 in Human
Applications
A03645 is guaranteed for ELISA, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
41.133kDa
Background of PAR4
Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
Hongzhe Li, J. Biol. Chem., Feb 2007; 282: 4943 - 4950.
Wuhan Xiao, Cancer Res., Aug 2003; 63: 4698 - 4704.
Thierry Virolle, J. Biol. Chem., Mar 2003; 278: 11802 - 11810.
Derek J. Richard, Genes & Dev., Feb 2001; 15: 328.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:500-1:2000
ELISA 1:5000
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Western blotting validation for Anti-Cleaved-PAR-4 (G48) F2RL3 Antibody A03645
Western Blot (WB) analysis of NIH-3T3 cells using Cleaved-PAR-4 (G48) polyclonal antibody.Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
Protein Target Info & Infographic
Gene/Protein Information For F2RL3 (Source: Uniprot.org, NCBI)
Gene Name
F2RL3
Full Name
Proteinase-activated receptor 4
Weight
41.133kDa
Superfamily
G-protein coupled receptor 1 family
Alternative Names
proteinase-activated receptor 4; coagulation factor II (thrombin) receptor-like 3; F2RL3; PAR4; Protease-Activated Receptor 4; Thrombin Receptor-like 3 F2RL3 PAR4 F2R like thrombin or trypsin receptor 3 proteinase-activated receptor 4|F2R like thrombin/trypsin receptor 3|PAR-4|coagulation factor II (thrombin) receptor-like 3|protease-activated receptor-4|thrombin receptor-like 3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on F2RL3, check out the F2RL3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for F2RL3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Cleaved-PAR-4 (G48) F2RL3 Antibody (A03645)
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No publications found for A03645
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