Anti-CLEC7A Antibody

Product Name

Anti-CLEC7A Antibody

View all CLEC7A Antibodies

SKU/Catalog Number

A02731

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-CLEC7A Antibody (Catalog # A02731). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

CLEC7A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-CLEC7A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02731)

Host

Rabbit

Contents

CLEC7A Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

CLEC7A antibody was raised against a 17 amino acid synthetic peptide near the center of human CLEC7A. The immunogen is located within amino acids 70 - 120 of CLEC7A.

Cross-reactivity

Multiple isoforms of CLEC7A are known to exist.

Reactive Species

A02731 is reactive to CLEC7A in Human, Mouse, Rat

Observed Molecular Weight

68 kDa

Calculated molecular weight

27.6 kDa

Background of CLEC7A

CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A02731 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

CLEC7A antibody can be used for detection of CLEC7A by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information CLEC7A

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