|Ig Isotype||Mouse IgG1|
|Product Name||Anti-Collagen, Type IV Antibody (Monoclonal, COL-94)|
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Mouse IgG monoclonal antibody for Collagen, Type IV, collagen, type IV, alpha-1; collagen, type IV, alpha 3 (Goodpasture antigen); collagen,type IV, alpha 4; collagen, type IV, alpha 5; collagen, type IV, alpha 6 (COL4A1; COL4A3; COL4A4; COL4A5; COL4A6) detection. Tested with IHC-P, IHC-F in Human. No cross reactivity with other proteins.|
|Cite This Product||Anti-Collagen, Type IV Antibody (Monoclonal, COL-94) (Boster Biological Technology, Pleasanton CA, USA, Catalog # MA1030)|
|Immunogen||Human collagen type IV.|
Assay Dilutions Overview
Immunohistochemistry(Frozen Section), 0.5-1μg/ml, Human
Boster's Secondary Antibodies And IHC, WB Kits
The following reagents are used to generate the images below.Boster recommends HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(P) and IHC(F).
Images And Assay Conditions
Anti-Collagen, Type IV antibody (monoclonal), MA1030, IHC(P)
IHC(P): Human Mammary Cancer Tissue
Protein Target Info (Source: Uniprot.org)
|Protein Name||Collagen alpha-1(IV) chain|
|Tissue Specificity||Highly expressed in placenta. .|
|Alternative Names||Collagen alpha-1(IV) chain;Arresten;COL4A1;|
|Subcellular Localization||Secreted, extracellular space, extracellular matrix, basement membrane.|
|Molecular Weight||160615 MW|
*if product is indicated to react with multiple species, protein info is based on the human gene.
|Protein Function||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|
|Background||Collagen IV is comprised of a third chain(alpha-3) together with the 2 classical ones, alpha-1 and alpha-2. COL4A3 gene is localized to 2q36-q37 by analysis of somatic cell hybrids and by in situ hybridization. The alpha-3 chain of type IV collagen induces autoimmune Goodpasture syndrome. Mutations in the COL4A4 and COL4A3 genes cause familial benign hematuria.|
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