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Product Info Summary
| SKU: | A11951 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-CRIM2 KCP Antibody
SKU/Catalog Number
A11951
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-CRIM2 KCP Antibody (Catalog # A11951). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
CRIM2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-CRIM2 KCP Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A11951)
Host
Rabbit
Contents
CRIM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
CRIM2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human CRIM2. The immunogen is located within amino acids 1320 - 1370 of CRIM2.
Cross-reactivity
At least two isoforms of CRIM2 are known to exist; this antibody will only detect the larger isoform. CRIM2 antibody is predicted to not cross-react with CRIM1.
Reactive Species
A11951 is reactive to KCP in Human, Mouse, Rat
Observed Molecular Weight
68 kDa
Calculated molecular weight
166.9 kDa
Background of KCP
CRIM2, also known as Kielin/chordin-like protein (KCP), is a novel enhancer of BMP signaling. It binds to BMP7, a morphogen that is important for kidney development and part of the kidney's physiological response to repair of acute kidney injury, enhancing its binding to its receptor. Because of this, CRIM2 has been suggested as a potential antifibrotic therapy in acute and chronic kidney injury. CRIM2 can also interact directly with either activin or TGF-β1, suppressing activin- and TGF-β1-dependent transcription.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A11951 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CRIM2 antibody can be used for detection of CRIM2 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of CRIM2 in Jurkat cell lysate with CRIM2 antibody at (A) 1 and (B) 2 μg/mL.
Specific Publications For Anti-CRIM2 KCP Antibody (A11951)
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