Anti-CTNNB1 Antibody (C-term)

beta-Catenin antibody

Boster Bio Anti-CTNNB1 Antibody (C-term) catalog # M00004-5. Tested in IF, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: M00004-5
Size: 50 ul
Reactive Species: Human, Mouse, Rat
Host: Mouse
Application: IF, WB

Customers Who Bought This Also Bought

Product Name

Anti-CTNNB1 Antibody (C-term)

View all beta-Catenin Antibodies

SKU/Catalog Number

M00004-5

Size

50 ul

Description

Boster Bio Anti-CTNNB1 Antibody (C-term) catalog # M00004-5. Tested in IF, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Cite This Product

Anti-CTNNB1 Antibody (C-term) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00004-5)

Host

Mouse

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

Clonality

Monoclonal

Isotype

IgG1

Immunogen

This CTNNB1 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 687-721 amino acids from the C-terminal region of human CTNNB1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M00004-5 is reactive to CTNNB1 in Human, Mouse, Rat

Applications

M00004-5 is guaranteed for IF, WB Boster Guarantee

Background of beta-Catenin

Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.

View more details

Innovating Scientists Reward

If you are the first to review this product, or if you have results for a special sample, species or application this product is not validated in, share your results with us and receive product credits you can use towards any Boster products! Applicable to all scientists worldwide.

Submit A Review

Validation Images & Assay Conditions

Gene/Protein Information For CTNNB1 (Source: Uniprot.org, NCBI)

Uniprot ID

P35222

Gene ID

1499

Gene Name

CTNNB1

Full Name

Catenin beta-1

Weight

85.497kDa

Superfamily

beta-catenin family

Alternative Names

bCatenin; beta 1 (88kD); beta-Catenin; catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta-1; CTNNB; CTNNB1; DKFZp686D02253; FLJ25606; FLJ37923 CTNNB1 CTNNB, EVR7, MRD19, NEDSDV, armadillo catenin beta 1 catenin beta-1|catenin (cadherin-associated protein), beta 1, 88kDa

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on CTNNB1, check out the CTNNB1 Infographic

CTNNB1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CTNNB1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected]

No publications found for M00004-5

*Do you have publications using this product? Share with us and receive a reward. Ask us for more details.

Have you used Anti-CTNNB1 Antibody (C-term)?

Submit a review and receive an Amazon gift card.

  • $25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
  • $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit A Review

Be the first to review Anti-CTNNB1 Antibody (C-term)

*The first user to submit a review for a product is eligible for Boster's Innovating Scientists Reward, which gives product credits. This is in addition to the gift card reward.

Have a question?

Find answers in Q&As, reviews.

Can't find your answer?

Submit your question

0 Customer Q&As for Anti-CTNNB1 Antibody (C-term)

Size

Total: $170

SKU:M00004-5

Ask a question

Get A Quote

Ships directly to USA and Canada. For other regions, visit our distributors page

Bulk Inquiry

In stock
Order Product
M00004-5
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$170.00

Troubleshooting

troubleshooting-box-image

Download troubleshooting handbooks for IHC, Western blot and ELISA for FREE.

Download Free PDFs Now

Boster Guarantee

Guaranteed product quality

Guaranteed product quality

We promise all of our products perform as described in datasheets.