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Product Info Summary
| SKU: | A13072 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-CXXC4 Antibody
SKU/Catalog Number
A13072
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-CXXC4 Antibody (Catalog # A13072). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
CXXC4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-CXXC4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A13072)
Host
Rabbit
Contents
CXXC4 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
Clone: SK7
Isotype
IgG
Immunogen
CXXC4 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CXXC4. The immunogen is located within amino acids 50 - 100 of CXXC4.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This antibody is predicted to have no cross-reactivity to other Rim proteins.
Reactive Species
A13072 is reactive to CXXC4 in Human, Mouse, Rat
Applications
A13072 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
20.978kDa
Background of CXXC4
CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CXXC4 antibody can be used for detection of CXXC4 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of CXXC4 in human brain tissue lysate with CXXC4 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of CXXC4 in human brain tissue with CXXC4 antibody at 10 μg/mL.
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Immunofluorescence of CXXC4 in human brain tissue with CXXC4 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For CXXC4 (Source: Uniprot.org, NCBI)
Gene Name
CXXC4
Full Name
CXXC-type zinc finger protein 4
Weight
20.978kDa
Alternative Names
CXXC finger protein 4; CXXC-type zinc finger protein 4; Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex); IDAXCXXC finger 4; Inhibition of the Dvl and axin complex protein; MGC149872 CXXC4 IDAX CXXC finger protein 4 CXXC-type zinc finger protein 4|CXXC finger 4|Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex)|inhibition of the Dvl and axin complex protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CXXC4, check out the CXXC4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CXXC4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CXXC4 Antibody (A13072)
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No publications found for A13072
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