Anti-SHP2/PTPN11 Antibody

SHP-2/PTPN11 antibody

Boster Bio Anti-SHP2/PTPN11 Antibody catalog # PA1114. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: PA1114
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IHC, WB

Product Name

Anti-SHP2/PTPN11 Antibody

View all SHP-2/PTPN11 Antibodies

SKU/Catalog Number

PA1114

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-SHP2/PTPN11 Antibody catalog # PA1114. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-SHP2/PTPN11 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1114)

Host

Rabbit

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human SHP2, identical to the related rat and mouse sequences.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1114 is reactive to PTPN11 in Human, Mouse, Rat

Applications

PA1114 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

70-74 kDa

Calculated molecular weight

68.011kDa

Background of SHP-2/PTPN11

The tyrosine phosphatase Shp2 is recruited into tyrosine-kinase signalling pathways through binding of its two amino-terminal SH2 domains to specific phosphotyrosine motifs, concurrent with its re-localization and stimulation of phosphatase activity. Shp2 can potentiate signalling through the MAP-kinase pathway and is required during early mouse development for gastrulation. Shp2 is specifically required in mesenchyme cells of the progress zone (PZ), directly beneath the distal ectoderm of the limb bud. Rather than integrating proliferative signals, Shp2 probably exerts its effects on limb development by influencing cell shape, movement or adhesion. Furthermore, the branchial arches, which also use Fgfs during bud outgrowth, similarly require Shp2. Thus, Shp2 regulates phosphotyrosine-signalling events during the complex ectodermal-mesenchymal interactions that regulate mammalian budding morphogenesis.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat
Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat

Validation Images & Assay Conditions

Gene/Protein Information For PTPN11 (Source: Uniprot.org, NCBI)

Gene Name

PTPN11

Full Name

Tyrosine-protein phosphatase non-receptor type 11

Weight

68.011kDa

Superfamily

protein-tyrosine phosphatase family

Alternative Names

BPTP3; EC 3.1.3.48; MGC14433; protein tyrosine phosphatase, non-receptor type 11; protein tyrosine phosphatase-2; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; PTP1D; PTP-1D; PTP2C; PTP-2C; PTP2CNS1; PTPN11; SHP2; SHP-2; SHP2CFC; SHPTP2; SH-PTP2; SH-PTP2Noonan syndrome 1; SH-PTP3; tyrosine-protein phosphatase non-receptor type 11 PTPN11 BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2 protein tyrosine phosphatase non-receptor type 11 tyrosine-protein phosphatase non-receptor type 11|SH2 domain-containing protein tyrosine phosphatase 2|protein-tyrosine phosphatase 1D|protein-tyrosine phosphatase 2C

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on PTPN11, check out the PTPN11 Infographic

PTPN11 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for PTPN11: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
PA1114

100μg

$370
PA1114-10ug

10μg sample (liquid)

$99
PA1114-Biotin

100 μg Biotin conjugated

$570
PA1114-Cy3

100 μg Cy3 conjugated

$570
PA1114-Dylight488

100 μg Dylight488 conjugated

$570
PA1114-Dylight550

100 μg Dylight550 conjugated

$570
PA1114-Dylight594

100 μg Dylight594 conjugated

$570
PA1114-FITC

100 μg FITC conjugated

$570
PA1114-HRP

100 μg HRP conjugated

$570
PA1114-APC

100 μg APC conjugated

$670
PA1114-PE

100 μg PE conjugated

$670
PA1114-carrier-free

Carrier Free

$370

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Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
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