Product Info Summary
SKU: | A00552-2 |
---|---|
Size: | 100ul |
Reactive Species: | Human |
Host: | Rabbit |
Application: | Flow Cytometry, IF, IHC, ICC, WB |
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Product info
Product Name
Anti-Cyclin-dependent kinase 7 Cdk7 Antibody
SKU/Catalog Number
A00552-2
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Cyclin-dependent kinase 7 Cdk7 Antibody catalog # A00552-2. Tested in WB,ICC/IF,IHC,Flow Cytometry applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Cyclin-dependent kinase 7 Cdk7 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00552-2)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human TRAP220 around the phosphorylation site of T1457.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A00552-2 is reactive to CDK7 in Human
Applications
A00552-2 is guaranteed for Flow Cytometry, IF, IHC, ICC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
39.038kDa
Background of CDK7
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Drane P., Oncogene 15:3013-3024(1997).
Yuan C.-X., Proc. Natl. Acad. Sci. U.S.A. 95:7939-7944(1998).
Naeaer A.M., Nature 398:828-832(1999).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:1,000
ICC: 1:100-1:500
IHC: 1:50-1:200
FC: 1:50-1:100
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Immunocytochemistry staining of CDK7 using Anti-Cyclin-dependent kinase 7 Cdk7 Antibody (A00552-2).
ICC staining Cdk7 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehydeClick image to see more details
Figure 2. Immunocytochemistry staining of CDK7 using Anti-Cyclin-dependent kinase 7 Cdk7 Antibody (A00552-2).
ICC staining Cdk7 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehydeProtein Target Info & Infographic
Gene/Protein Information For CDK7 (Source: Uniprot.org, NCBI)
Gene Name
CDK7
Full Name
Cyclin-dependent kinase 7
Weight
39.038kDa
Superfamily
protein kinase superfamily
Alternative Names
CAK1Xenopus laevis, cdk-activating kinase); CDK-activating kinase; Cell division protein kinase 7; cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase); cyclin-dependent kinase 7; EC 2.7.11; EC 2.7.11.22; EC 2.7.11.23; EC 2.7.11.24; p39 Mo15; serine/threonine kinase stk1,39 kDa protein kinase; serine/threonine protein kinase 1; serine/threonine protein kinase MO15; TFIIH basal transcription factor complex kinase subunit CDK7 CAK, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15 cyclin dependent kinase 7 cyclin-dependent kinase 7|39 KDa protein kinase|CDK-activating kinase 1|TFIIH basal transcription factor complex kinase subunit|cell division protein kinase 7|cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)|homolog of Xenopus MO15 Cdk-activating kinase|kinase subunit of CAK|serine/threonine kinase stk1|serine/threonine protein kinase 1|serine/threonine protein kinase MO15
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CDK7, check out the CDK7 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CDK7: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Cyclin-dependent kinase 7 Cdk7 Antibody (A00552-2)
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No publications found for A00552-2
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