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- Table of Contents
Cyclin-dependent kinase 7 Antibodies
AND CDK7 ELISA kits, Cyclin-dependent kinase 7 Proteins
Many biological assays use antibodies to detect Cyclin-dependent kinase 7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cyclin-dependent kinase 7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cyclin-dependent kinase 7 antibodies...
Designing a Western blot for Cyclin-dependent kinase 7? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CDK7 Western Blot GuideCDK7 Infographic by Boster Bio
All CDK7 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$370
Cat # PA2126-1
100 μg/vial
Cat # PA2126-1
100 μg/vial
Human, Mouse, Rat
WB
$370
Cat # PA2126-2
100 μg/vial
Cat # PA2126-2
100 μg/vial
Human, Mouse
IF, IHC, ICC, WB
$405
Cat # A00552-1
100ul
Cat # A00552-1
100ul
Human, Mouse
ELISA
$540
Cat # EKC2234
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2234
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA
$480
Cat # EKC1110
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1110
1 kit, containing one 96-well plate and all necessary reagents
Human
Flow Cytometry, IF, IHC, ICC, WB
$405
Cat # A00552-2
100ul
Cat # A00552-2
100ul
CDK7 Overview
Facts about Cyclin-dependent kinase 7.
Cyclin-dependent kinase 7 (CDK7)
Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin- dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle.
Each different complex controls a specific transition between two subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (although not complex formation).
Gene Information
| Human | |
|---|---|
| Gene Name: | CDK7 |
| Uniprot: | P50613 |
| Entrez: | 1022 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
CAK1Xenopus laevis, cdk-activating kinase); CDK-activating kinase; Cell division protein kinase 7; cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase); cyclin-dependent kinase 7; EC 2.7.11; EC 2.7.11.22; EC 2.7.11.23; EC 2.7.11.24; p39 Mo15; serine/threonine kinase stk1,39 kDa protein kinase; serine/threonine protein kinase 1; serine/threonine protein kinase MO15; TFIIH basal transcription factor complex kinase subunit
Molecular Weight
Mass (kDA):
39.038 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q13.2 |
| Sequence: | 5; NC_000005.10 (69234795..69277430) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Colocalizes with PRKCI in the cytoplasm and nucleus. Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Retinoblastoma
- Malignant Paraganglionic Neoplasm
- Xeroderma
- Leukemia
- Xeroderma Pigmentosum
- Mammary Neoplasms
- Hiv Infections
- Immunologic Deficiency Syndromes
- Malignant Neoplasm Of Breast
- Liver Carcinoma
Interacting Proteins
- CDK2
- CDK4
- E2F1
- HSP90AB1
- SUPT5H
Pathways
- Cell Cycle
- Dna Repair
- Cell Cycle Arrest
- Cell Proliferation
- Cell Division
- Mitosis
- Localization
- Cell Growth
- Hyperphosphorylation
- Cell Death
- S Phase
- G1 Phase
- Induction Of Apoptosis
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Methylation
- Acetylation
Research Areas
- Cell Cycle and Replication
- DNA Repair
- Nucleotide Excision Repair
- Signal Transduction
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDK7
bosterbio.com/bosterbio-gene-info-cards/CDK7
References
PMID: 7929589 by Tassan J.-P., et al. Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).
PMID: 8208544 by Levedakou E.N., et al. Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern.