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Product Info Summary
| SKU: | A04048-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-DcR3 TNFRSF6B Antibody
View all DcR3/TNFRSF6B Antibodies
SKU/Catalog Number
A04048-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-DcR3 TNFRSF6B Antibody (Catalog # A04048-1). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
DcR3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-DcR3 TNFRSF6B Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04048-1)
Host
Rabbit
Contents
DcR3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
DcR3 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human DcR3 precursor. The immunogen is located within the first 50 amino acids of DcR3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
ADRM1 antibody is human, mouse and rat reactive. At least two isoforms of ADRM1 are know to exist; this antibody will detect both isoforms.
Reactive Species
A04048-1 is reactive to TNFRSF6B in Human, Mouse, Rat
Applications
A04048-1 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
32.68kDa
Background of DcR3/TNFRSF6B
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively,. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis. DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
DcR3 antibody can be used for detection of DcR3 expression by Western blot 0.5 μg/mL. An approximately 33 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 1 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of DcR3 in human heart (H)
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Immunohistochemistry of DcR3 in human heart tissue with DcR3 antibody at 1 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TNFRSF6B (Source: Uniprot.org, NCBI)
Gene Name
TNFRSF6B
Full Name
Tumor necrosis factor receptor superfamily member 6B
Weight
32.68kDa
Alternative Names
DcR3; DCR3Decoy receptor for Fas ligand; Decoy receptor 3; M68; M68DJ583P15.1.1; TNFRSF6B; TR6; TR6DcR3; tumor necrosis factor receptor superfamily member 6B; tumor necrosis factor receptor superfamily, member 6b, decoy TNFRSF6B DCR3, DJ583P15.1.1, M68, M68E, TR6 TNF receptor superfamily member 6b tumor necrosis factor receptor superfamily member 6B|decoy receptor 3 variant 1|decoy receptor 3 variant 2|decoy receptor for Fas ligand|tumor necrosis factor receptor superfamily, member 6b, decoy
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TNFRSF6B, check out the TNFRSF6B Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TNFRSF6B: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-DcR3 TNFRSF6B Antibody (A04048-1)
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