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Product Info Summary
| SKU: | M02655 |
|---|---|
| Size: | 100ug/vial |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | IHC |
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Product info
Product Name
Anti-Desmoglein-1 (DSG1) Monoclonal Antibody
SKU/Catalog Number
M02655
Size
100ug/vial
Form
Liquid
Description
Boster Bio Anti-Desmoglein-1 (DSG1) Monoclonal Antibody (Catalog # M02655). Tested in IHC applications. This antibody reacts with Human.
Storage & Handling
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Cite This Product
Anti-Desmoglein-1 (DSG1) Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M02655)
Host
Mouse
Contents
Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Clonality
Monoclonal
Clone Number
Clone: DSG1/1733
Isotype
IgG1, kappa
Immunogen
Recombinant human desmoglein-1 protein fragment corresponding to intracellular domain
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Does not cross-react with primate, avian or amphibian GR.
Reactive Species
M02655 is reactive to DSG1 in Human
Applications
M02655 is guaranteed for IHC Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
113.748kDa
Background of DSG1
Recognizes a protein of ~150kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family.Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Reconsitution
Reconstitute with distilled water.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris buffer with 1mM EDTA, pH 8.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
Validation Images & Assay Conditions
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Formalin-fixed, paraffin-embedded human skin stained with Anti-Desmoglein-1 Monoclonal Antibody (DSG1/1733).
Protein Target Info & Infographic
Gene/Protein Information For DSG1 (Source: Uniprot.org, NCBI)
Gene Name
DSG1
Full Name
Desmoglein-1
Weight
113.748kDa
Alternative Names
Cadherin family member 4; CDHF4; CDHF4PPKS1; desmoglein 1; Desmoglein1; Desmoglein-1; Desmosomal glycoprotein 1; DG1; DGI; DSG; DSG1; Pemphigus foliaceus antigen; SPPK1 DSG1 CDHF4, DG1, DSG, EPKHE, EPKHIA, PPKS1, SPPK1 desmoglein 1 desmoglein-1|cadherin family member 4|desmosomal glycoprotein 1|pemphigus foliaceus antigen
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on DSG1, check out the DSG1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for DSG1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Desmoglein-1 (DSG1) Monoclonal Antibody (M02655)
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No publications found for M02655
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