Desmoglein-1 Antibodies

AND DSG1 ELISA kits, Desmoglein-1 Proteins

Many biological assays use antibodies to detect Desmoglein-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Desmoglein-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Desmoglein-1 antibodies...

We validate the specificity of these antibodies to Desmoglein-1 by testing them on tissues known to express DSG1 positively and negatively. Browse below to find the DSG1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for Desmoglein-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the DSG1 Western Blot Guide

Designing an IHC experiment for Desmoglein-1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the DSG1 IHC Guide

DSG1 Infographic by Boster Bio

All DSG1 Products

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Product

Figures

Specificity

Applications

Price

Anti-DSG1/Desmoglein 1 Rabbit Monoclonal Antibody

Western blot analysis of DSG1 expression in human skin lysate

IHC analysis of DSG1 using anti-DSG1 antibody (M02655-1)

Human, Mouse, Rat

IF, IHC, ICC, WB

$370
Cat # M02655-1
100 μl

Anti-Dsg1/Desmoglein 1 Antibody

Immunohistochemical analysis of paraffin-embedded human-skin, antibody was diluted at 1:200

Western blot analysis of 293T lysate, antibody was diluted at 1000

Human, Mouse, Rat

ELISA, IF, IHC, WB

$399
Cat # A02655-1
100μl

DSG1 Overview

Facts about Desmoglein-1.

DSG1 3D structure. Source: alphafold

Desmoglein-1 (DSG1)

Part of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Gene Information

Human
Gene Name:	DSG1
Uniprot:	Q02413
Entrez:	1828

Family

Belongs to:

No superfamily

Alternative Names

Cadherin family member 4; CDHF4; CDHF4PPKS1; desmoglein 1; Desmoglein1; Desmoglein-1; Desmosomal glycoprotein 1; DG1; DGI; DSG; DSG1; Pemphigus foliaceus antigen; SPPK1

Molecular Weight

Mass (kDA):
113.748 kDA

Genomic Context


Human

Location:	18q12.1
Sequence:	18; NC_000018.10 (31318160..31359246)

Tissue Specificity

Epidermis, tongue, tonsil and esophagus.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.

Diseases

Pemphigus Foliaceus
Tissue Adhesions
Bulla
Autoimmune Reaction
Dermatologic Disorders
Autoimmune Diseases
Acantholysis
Mucinous Adenocarcinoma
Brazilian Pemphigus Foliaceus
Neoplasms

Bullous Pemphigoid
Staphylococcal Scalded Skin Syndrome
Palmoplantar Keratosis
Autoimmunity
Dental Plaque

Pathways

Cell Adhesion
Pathogenesis
Cell-cell Adhesion
Localization
Proteolysis
Desmosome Assembly
Keratinocyte Differentiation
Anagen
Telogen
Secretion
Keratinization
Translation
Catagen

Immune Response
Rna Interference
Hair Follicle Development
Cell Activation
T Cell Activation
Cytoskeleton Organization
Cell Cycle

PTMs

Cleavage
Phosphorylation

Glycosylation
Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DSG1

References

PMID: 1711210 by Wheeler G.N., et al. Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules.

PMID: 1770008 by Nilles L.A., et al. Structural analysis and expression of human desmoglein: a cadherin- like component of the desmosome.