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Product Info Summary
| SKU: | A01736 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-DIS3 Antibody
SKU/Catalog Number
A01736
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-DIS3 Antibody (Catalog # A01736). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
DIS3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-DIS3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01736)
Host
Rabbit
Contents
DIS3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
DIS3 antibody was raised against an 18 amino acid peptide near the amino terminus of human DIS3. The immunogen is located within amino acids 90 - 140 of DIS3.
Cross-reactivity
Multiple isoforms of DIS3 are known to exist.
Reactive Species
A01736 is reactive to DIS3 in Human, Mouse, Rat
Observed Molecular Weight
68 kDa
Calculated molecular weight
109.0 kDa
Background of DIS3
The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01736 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
DIS3 antibody can be used for detection of DIS3 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of DIS3 in human ovary tissue lysate with DIS3 antibody at 1 μg/mL.
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Immunohistochemistry of DIS3 in mouse testis tissue with DIS3 antibody at 2.5 μg/ml.
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Immunofluorescence of DIS3 in mouse testis tissue with DIS3 antibody at 20 μg/ml.
Specific Publications For Anti-DIS3 Antibody (A01736)
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