Anti-DIS3 Antibody

DIS3 antibody

Boster Bio Anti-DIS3 Antibody (Catalog # A01736). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: A01736
Size: 0.1 mg
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: ELISA, IF, IHC-P, WB

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Product Name

Anti-DIS3 Antibody

View all DIS3 Antibodies

SKU/Catalog Number

A01736

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-DIS3 Antibody (Catalog # A01736). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

DIS3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Cite This Product

Anti-DIS3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01736)

Host

Rabbit

Contents

DIS3 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

DIS3 antibody was raised against an 18 amino acid peptide near the amino terminus of human DIS3. The immunogen is located within amino acids 90 - 140 of DIS3.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

Multiple isoforms of DIS3 are known to exist.

Reactive Species

A01736 is reactive to DIS3 in Human, Mouse, Rat

Reconstitution

Observed Molecular Weight

68 kDa

Calculated molecular weight

109003 MW

Background of DIS3

The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A01736 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

DIS3 antibody can be used for detection of DIS3 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For DIS3 (Source: Uniprot.org, NCBI)

Gene Name

DIS3

Full Name

Exosome complex exonuclease RRP44

Weight

109003 MW

Superfamily

RNR ribonuclease family

Alternative Names

RRP44, dis3p, EXOSC11, KIAA1008, 2810028N01Rik, RRP44, Exosome complex exonuclease RRP44, Protein DIS3 homolog DIS3 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p DIS3 homolog, exosome endoribonuclease and 3-5 exoribonuclease exosome complex exonuclease RRP44|DIS3 exosome endoribonuclease and 3-5 exoribonuclease|DIS3 mitotic control homolog|exosome component 11|mitotic control protein dis3 homolog|ribosomal RNA-processing protein 44

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on DIS3, check out the DIS3 Infographic

DIS3 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for DIS3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A01736-0.1 mg

0.1 mg

$449

Free Secondary Antibody

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A01736
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$449.00

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