Anti-DISC1 Antibody

DISC1 antibody

Boster Bio Anti-DISC1 Antibody catalog # PA2023-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: PA2023-1
Size: 100μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IHC, WB

Product Name

Anti-DISC1 Antibody

View all DISC1 Antibodies

SKU/Catalog Number

PA2023-1

Size

100μg/vial

Form

Lyophilized

Description

Boster Bio Anti-DISC1 Antibody catalog # PA2023-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-DISC1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA2023-1)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human DISC1 (461-477aa EKQQLQKEIEALQARMF), different from the related mouse sequence by two amino acids, and from the related rat sequence by four amino acids.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross Reactivity

No cross reactivity with other proteins

Reactive Species

PA2023-1 is reactive to DISC1 in Human, Mouse, Rat

Applications

PA2023-1 is guaranteed for IHC, WB Boster Guarantee

Background of DISC1

DISC1 (Disrupted in Schizophrenia 1), is a protein that is encoded by the DISC1 gene in humans. Ma et al. (2002) determined that the mouse Disc1 gene maps to chromosome 8 in a region with homology of synteny to human chromosome 1q42. Ozeki et al. (2003) demonstrated that rodent Disc1 expression displayed pronounced developmental regulation, with the highest levels in late embryonic life during development of the cerebral cortex. Millar et al. (2005) showed that DISC1 interacts with the UCR2 domain of phosphodiesterase-4B, implicated in susceptibility to schizophrenia, and that elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and in increase in PDE4B activity.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse

Validation Images & Assay Conditions

Gene/Protein Information For DISC1 (Source: Uniprot.Org, NCBI)

Uniprot ID

Q9NRI5

Gene ID

27185

Gene Name

DISC1

Full Name

Disrupted in schizophrenia 1 protein

Weight

93.611kDa

Alternative Names

C1orf136; DISC1; disrupted in schizophrenia 1 protein; disrupted in schizophrenia 1; FLJ13381; FLJ21640; FLJ25311; FLJ41105; KIAA0457; SCZD9 DISC1 C1orf136, SCZD9 DISC1 scaffold protein disrupted in schizophrenia 1 protein

*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".

For more info on DISC1, check out the DISC1 Infographic

DISC1 infographic

We have 30,000+ of these available, one for each gene! check them out.

In this infographic you will see the following information for DISC1: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected]

No publications found for PA2023-1

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1 Customer Q&As for Anti-DISC1 Antibody

Question

We are currently using anti-DISC1 antibody PA2023-1 for rat tissue, and we are well pleased with the IHC results. The species of reactivity given in the datasheet says human, mouse, rat. Is it likely that the antibody can work on pig tissues as well?

L. Thomas

Verified customer

Asked: 2014-07-10

Answer

The anti-DISC1 antibody (PA2023-1) has not been validated for cross reactivity specifically with pig tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in pig you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2014-07-10

Size

Total: $315

SKU:PA2023-1

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Boster offers all the reagents you need for your immunostaining and western blotting experiments. We've got everything from buffers to lysates to kits, including our popular and well-cited BCA, CCK-8, and MTT assay kits.

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PA2023-1
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$315.00

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