Product Info Summary
SKU: | A02978 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | ELISA, IHC-P, IF (paraffin) |
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Product info
Product Name
Anti-DMC1 Antibody
SKU/Catalog Number
A02978
Size
100ul
Form
Liquid
Description
Boster Bio Anti-DMC1 Antibody (Catalog# A02978). Tested in IHC-P, IF (paraffin), ELISA applications. This antibody reacts with Human, Mouse.
Storage & Handling
Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-DMC1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02978)
Host
Rabbit
Contents
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
7A7
Isotype
Rabbit IgG
Immunogen
A peptide derived from human DMC1. Immunogen sequence location: 61-110
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A02978 is reactive to DMC1 in Human, Mouse
Applications
A02978 is guaranteed for ELISA, IHC-P, IF (paraffin) Boster Guarantee
Observed Molecular Weight
72 kDa
Calculated molecular weight
37.681kDa
Background of DMC1
Integrin alpha 1 (ITGA1) chain associates with the beta 1 (ITGB1) chain to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a C-terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation sites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180-kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of mesenchymal stem cell proliferation and cartilage production. It also plays an essential role in the regulation of MSC proliferation and cartilage production.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Innovating Scientists Reward
If you are the first to review this product, or if you have results for a special sample, species or application this product is not validated in, share your results with us and receive product credits you can use towards any Boster products! Applicable to all scientists worldwide.
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Assay dilution & Images
Reconsitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Immunohistochemistry, 1:100 - 1:300
ELISA, 1:10000
Not yet tested in other applications.
Validation Images & Assay Conditions
![DMC1 primary antibodies A02978 IHC testing DMC1 primary antibodies A02978 IHC testing](https://www.bosterbio.com/media/catalog/product/D/M/DMC1-primary-antibodies-A02978-IHC-testing.jpg)
Click image to see more details
Immunohistochemistry analysis of paraffin-embedded human heart tissue, using DMC1 Antibody. The picture on the right is blocked with the synthesized peptide.
Protein Target Info & Infographic
Gene/Protein Information For DMC1 (Source: Uniprot.org, NCBI)
Gene Name
DMC1
Full Name
Meiotic recombination protein DMC1/LIM15 homolog
Weight
37.681kDa
Superfamily
RecA family
Alternative Names
disrupted meiotic cDNA1, yeast, homolog of; DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologousrecombination (yeast); DMC1 homologue; HsLim15; LIM15yeast homolog) meiosis-specific homologousrecombination; meiotic recombination protein DMC1/LIM15 homolog; MGC150472; MGC150473 DMC1 DMC1H, LIM15, dJ199H16.1 DNA meiotic recombinase 1 meiotic recombination protein DMC1/LIM15 homolog|DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination|disrupted meiotic cDNA1, yeast, homolog of
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on DMC1, check out the DMC1 Infographic
![DMC1 infographic](/media/images/gene-infographic-example.jpg)
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for DMC1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-DMC1 Antibody (A02978)
Hello CJ!
No publications found for A02978
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Recommended Resources
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Customer Reviews
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Customer Q&As
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Find answers in Q&As, reviews.
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3 Customer Q&As for Anti-DMC1 Antibody
Question
Does anti-DMC1 antibody A02978 work for IHC with buccal mucosa cell?
Verified Customer
Verified customer
Asked: 2019-06-05
Answer
According to the expression profile of buccal mucosa cell, DMC1 is highly expressed in buccal mucosa cell. So, it is likely that anti-DMC1 antibody A02978 will work for IHC with buccal mucosa cell.
Boster Scientific Support
Answered: 2019-06-05
Question
We are currently using anti-DMC1 antibody A02978 for mouse tissue, and we are content with the IHC results. The species of reactivity given in the datasheet says human, mouse. Is it true that the antibody can work on pig tissues as well?
Verified Customer
Verified customer
Asked: 2018-01-10
Answer
The anti-DMC1 antibody (A02978) has not been tested for cross reactivity specifically with pig tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in pig you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2018-01-10
Question
My question regards to test anti-DMC1 antibody A02978 on human buccal mucosa cell for research purposes, then I may be interested in using anti-DMC1 antibody A02978 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?
L. Brown
Verified customer
Asked: 2016-12-13
Answer
The products we sell, including anti-DMC1 antibody A02978, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.
Boster Scientific Support
Answered: 2016-12-13