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Product Info Summary
| SKU: | A12371-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-Dynein light chain 1, axonemal DNAL1 Antibody
SKU/Catalog Number
A12371-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Dynein light chain 1, axonemal DNAL1 Antibody (Catalog # A12371-1). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
DNAL1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Dynein light chain 1, axonemal DNAL1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A12371-1)
Host
Rabbit
Contents
DNAL1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
DNAL1 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human DNAL1. The immunogen is located within the last 50 amino acids of DNAL1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least four isoforms of RGS22 are known to exist; this antibody will detect the three longest isoforms. RGS22 antibody is predicted to not cross-react with other RGS proteins
Reactive Species
A12371-1 is reactive to DNAL1 in Human, Mouse, Rat
Applications
A12371-1 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
21.533kDa
Background of DNAL1
DNAL1 was identified as a potential candidate gene for primary ciliary dyskinesia (PCD), a genetically heterologous disorder characterized by chronic infections of the upper and lower airways that often leads to permanent lung damage, randomization of left/right body symmetry, and reduced fertility. DNAL1 is reported to be expressed solely in tissues carrying motile cilia for flagella and interacts with DNAH5, a protein that when mutated has been shown to result in PCD. It has been suggested that DNAL1 serves a regulatory function for DNAH5 activity in outer dynein arms of sperm flagella, respiratory cilia, and ependymal cilia. DNAL1 has also been recently identified as an HIV dependency factor (HDF), suggesting that DNAL1 may be an important drug target in HIV treatment. At least two isoforms of DNAL1 are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
DNAL1 antibody can be used for detection of DNAL1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Immunofluorescence of DNAL1 in 3T3 cells with DNAL1 antibody at 20 μg/mL.
Green: DNAL1 Antibody (A12371-1)
Blue: DAPI staining
Protein Target Info & Infographic
Gene/Protein Information For DNAL1 (Source: Uniprot.org, NCBI)
Gene Name
DNAL1
Full Name
Dynein light chain 1, axonemal
Weight
21.533kDa
Superfamily
dynein light chain LC1-type family
Alternative Names
C14orf168MGC12435,1700010H15RiK; chromosome 14 open reading frame 168; dynein light chain 1, axonemal; dynein, axonemal, light chain 1 DNAL1 C14orf168, CILD16, LC1 dynein axonemal light chain 1 dynein light chain 1, axonemal
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on DNAL1, check out the DNAL1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for DNAL1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Dynein light chain 1, axonemal DNAL1 Antibody (A12371-1)
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No publications found for A12371-1
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