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Product Info Summary
| SKU: | A11139 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-EFCAB4B CRACR2A Antibody
SKU/Catalog Number
A11139
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-EFCAB4B CRACR2A Antibody (Catalog # A11139). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
EFCAB4B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-EFCAB4B CRACR2A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A11139)
Host
Rabbit
Contents
EFCAB4B Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
EFCAB4B antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human EFCAB4B. The immunogen is located within amino acids 640 - 690 of EFCAB4B.
Reactive Species
A11139 is reactive to EFCAB4B in Human, Mouse
Observed Molecular Weight
68 kDa
Calculated molecular weight
45.6 kDa
Background of EFCAB4B
EFCAB4B, also known as Calcium release-activated calcium channel regulator 2A, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation. EFCAB4B acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration. A closely related protein, EFCAB4A, is likely to play a similar role as EFCAB4B, but the detailed function of EFCAB4A is still under investigation.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A11139 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
EFCAB4B antibody can be used for detection of EFCAB4B by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of EFCAB4B in mouse kidney tissue lysate with EFCAB4B antibody at 1 μg/mL.
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Immunohistochemistry of EFCAB4B in human kidney tissue with EFCAB4B antibody at 10 μg/mL.
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Immunofluorescence of EFCAB4B in human kidney tissue with EFCAB4B antibody at 20 μg/mL.
Specific Publications For Anti-EFCAB4B CRACR2A Antibody (A11139)
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