Product Info Summary
SKU: | A04387 |
---|---|
Size: | 50μg/vial |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | IHC, WB |
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Product info
Product Name
Anti-EIF2 Alpha Eif2s1 Antibody
View all eIF2 alpha/EIF2S1 Antibodies
SKU/Catalog Number
A04387
Size
50μg/vial
Form
Liquid
Description
Boster Bio Anti-EIF2 Alpha Eif2s1 Antibody catalog # A04387. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-EIF2 Alpha Eif2s1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04387)
Host
Rabbit
Contents
Each vial contains 0.09% sodium azide and 50% glycerol.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthetic peptide corresponding to a portion of rat eIF2-alpha .
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A04387 is reactive to EIF2S1 in Human, Mouse, Rat
Applications
A04387 is guaranteed for IHC, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
36.112kDa
Background of eIF2 alpha/EIF2S1
EIF2S1 (Eukaryotic Translation Initiation Factor 2, Subunit 1), also called EIF2-alpha, is a protein that in humans is encoded by the EIF2S1 gene. Hartz (2010) mapped the EIF2S1 gene to chromosome 14q23.3 based on an alignment of the EIF2S1 sequence with the genomic sequence (GRCh37). Ernst et al. (1987) stated that protein synthesis is inhibited due to phosphorylation of Eif2-alpha in hemin-deprived rabbit reticulocyte lysates. HeLa cells subjected to heat shock, serum deprivation, or interferon treatment followed by virus infection also show a correlation between EIF2-alpha phosphorylation and translational repression. Jacob et al. (1989) found that the alpha-Pal transcription factor bound to 2 palindromic sites within the EIF2-alpha promoter and was essential for transcription of the EIF2-alpha gene.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB, 1μg/ml, ECL, Human, Mouse, Rat
Validation Images & Assay Conditions
Click image to see more details
EIF2 Alpha was detected in paraffin-embedded sections of human pancreas tissues using rabbit anti-EIF2 Alpha Antigen Affinity purified polyclonal antibody (Catalog # A04387) at 10 μg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022).
Click image to see more details
EIF2 Alpha was detected in paraffin-embedded sections of human prostate tissues using rabbit anti-EIF2 Alpha Antigen Affinity purified polyclonal antibody (Catalog # A04387) at 10 μg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022).
Click image to see more details
EIF2 Alpha was detected in paraffin-embedded sections of human vessel tissues using rabbit anti-EIF2 Alpha Antigen Affinity purified polyclonal antibody (Catalog # A04387) at 10 μg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022).
Click image to see more details
Western blot analysis of EIF2 Alpha expression in NIH3T3 whole cell lysates (lane 1). EIF2 Alpha at 36KD was detected using rabbit anti-EIF2 Alpha Antigen Affinity purified polyclonal antibody (Catalog # A04387) at 1 μg/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002).
Protein Target Info & Infographic
Gene/Protein Information For EIF2S1 (Source: Uniprot.org, NCBI)
Gene Name
EIF2S1
Full Name
Eukaryotic translation initiation factor 2 subunit 1
Weight
36.112kDa
Superfamily
eIF-2-alpha family
Alternative Names
eIF2 alpha; EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha; EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; EIF2S1 EIF2S1 EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A eukaryotic translation initiation factor 2 subunit alpha eukaryotic translation initiation factor 2 subunit 1|eIF-2-alpha|eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on EIF2S1, check out the EIF2S1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for EIF2S1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-EIF2 Alpha Eif2s1 Antibody (A04387)
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