Anti-Eotaxin 3/CCL26 Antibody
Rabbit IgG polyclonal antibody for C-C motif chemokine 26(CCL26) detection. Tested with WB in Human.
Anti-Eotaxin 3/CCL26 Antibody Info At A Glance
JAM3 belongs to the junctional adhesion molecule protein family and functions as a receptor for another member of this family. JAM3 plays a part in cell-cell adhesion. The soluble form of JAM3 is a mediator of angiogenesis. JAM3 is a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). A mutation in an intron of the JAM3 gene is linked with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts.
|Product Name||Anti-Eotaxin 3/CCL26 Antibody
See all CCL26/Eotaxin-3 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for Eotaxin 3/CCL26 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. Eotaxin 3/CCL26 information: Molecular Weight: 10648 MW; Subcellular Localization: Secreted; Tissue Specificity: Ubiquitously expressed at low levels in various tissues including heart and ovary.|
|Cite This Product||Anti-Eotaxin 3/CCL26 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1451)|
|Similar Products From
|Anti-Eotaxin 3/CCL26 Antibody may replace the following items: sc 377392|sc 101496|sc 101497|sc 68399|sc 376725|sc 66256|sc 66254|sc 136021.|
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human Eotaxin 3(73-94aa CTHPRKKWVQKYISLLKTPKQL).|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For CCL26 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||10344|
|Species Of This Entry||Human|
|Protein Name||C-C motif chemokine 26|
|Superfamily||intercrine beta (chemokine CC) family|
|Alternative Names||CCL26/Eotaxin-3|CC chemokine IMAC; C-C motif chemokine 26; CCL26; chemokine (C-C motif) ligand 26; chemokine N1; Eotaxin3; Eotaxin-3; IMAC; Macrophage inflammatory protein 4-alpha; MGC126714; MIP-4a; MIP-4alpha; SCYA26; SCYA26MIP-4-alpha; small inducible cytokine A26; small inducible cytokine subfamily A (Cys-Cys), member 26; Small-inducible cytokine A26; TSC-1Thymic stroma chemokine-1|
|Post Tranlational Modifications||Phosphorylation; Citrullination; Deacetylation; Acetylation|
|Gene Location||7q11.23, on Chromasome 7, gene sequence: NC_000007.14 (75769524..75791597, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For CCL26 (Source: Uniprot.org, NCBI)
|Protein Function||Chemoattractant for eosinophils and basophils (PubMed:10415065, PubMed:10488147). Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils (PubMed:10415065, PubMed:10488147, PubMed:11425309).|
|Tissue Specificity||Ubiquitously expressed at low levels in various tissues including heart and ovary.|
|Interacting Proteins||CCL13; CCL17; CCL21; CCL28; CCL5; CXCL10; CXCL11; CXCL12; CXCL14; CXCL9; PF4; XCL1|
|Related Diseases||Inflammation; Asthma; Cholangiocarcinoma; Eosinophilia; Esophagitis; Dermatitis; Dermatitis, Atopic; Eosinophilic Esophagitis; Dermatologic Disorders; Rhinorrhea; Allergy; Polyps; Neoplasms; Allergic Asthma; Tissue Adhesions; Sclerosis; Nasal Polyps; Tuberous Sclerosis; Chronic Sinusitis|
|Related Pathways||Pathogenesis; Chemotaxis; Secretion; Immune Response; Angiogenesis; Eosinophil Migration; Localization; Cell Growth; Cell Migration; Reverse Transcription; Cell Differentiation; Exocytosis; Cell Proliferation; Cell Adhesion; Superoxide Anion Generation; Sensitization; Chemokine Secretion; Epithelial Cell Differentiation; Eosinophil Activation; Eosinophil Extravasation|
|Background||Eotaxin-3 is a small cytokine belonging to the CC chemokine family that is also called CCL26, Chemokine(C-C motif) ligand 26. Chemokines play pivotal roles in health and disease by controlling migration and tissue localization of specific types of cells expressing their cognate receptors. Eotaxin-3 is chemotactic for eosinophils and basophils and elicits its effects by binding to the cell surface chemokine receptor CCR3. It is expressed by several tissues including heart, lung and ovary, and in endothelial cells that have been stimulated with the cytokine interleukin 4. This gene for chemokine is located on human chromosome 7. Eotaxin-3 induced migration of eosinophils and basophils only at a 10-fold higher concentration than eotaxin.|
|Scientific References||PMID: 10373330 by Guo R.F., et al. Molecular cloning and characterization of a novel human CC chemokine, SCYA26.|
PMID: 10415065 by Shinkai A., et al. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4- stimulated vascular endothelial cells, exhibits potent activity toward eosinophils.
Our Boster Quality Guarantee for Anti-Eotaxin 3/CCL26 Antibody covers its use in the following applications.Western blot, 0.1-0.5μg/ml, Human
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
All lanes: Anti Eotaxin3 (PA1451) at 0.5ug/ml
Lane 1: COLO320 Whole Cell Lysate at 40ug
Lane 2: A549 Whole Cell Lysate at 40ug
Predicted bind size: 11KD
Observed bind size: 11KD
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