C-C motif chemokine 26 Antibodies

C-C motif chemokine 26 (CCL26)

Chemoattractant for eosinophils and basophils (PubMed:10415065, PubMed:10488147). Acts as a ligand for C-C chemokine receptor CCR3 which activates Ca(2+) mobilization in eosinophils (PubMed:10415065, PubMed:10488147, PubMed:11425309).

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Gene Information

Human
Gene Name:	CCL26
Uniprot:	Q9Y258
Entrez:	10344

Family

Belongs to:
intercrine beta (chemokine CC) family

Alternative Names

CC chemokine IMAC; C-C motif chemokine 26; CCL26; chemokine (C-C motif) ligand 26; chemokine N1; Eotaxin3; Eotaxin-3; IMAC; Macrophage inflammatory protein 4-alpha; MGC126714; MIP-4a; MIP-4alpha; SCYA26; SCYA26MIP-4-alpha; small inducible cytokine A26; small inducible cytokine subfamily A (Cys-Cys), member 26; Small-inducible cytokine A26; TSC-1Thymic stroma chemokine-1

Molecular Weight

Mass (kDA):
10.648 kDA

Genomic Context

Human
Location:	7q11.23
Sequence:	7; NC_000007.14 (75769524..75791597, complement)

Tissue Specificity

Ubiquitously expressed at low levels in various tissues including heart and ovary.

Subcellular Localizations

Secreted.

Diseases

• Inflammation
• Asthma
• Cholangiocarcinoma
• Eosinophilia
• Esophagitis
• Dermatitis
• Dermatitis, Atopic
• Eosinophilic Esophagitis
• Dermatologic Disorders
• Rhinorrhea
• Allergy
• Polyps

• Neoplasms
• Allergic Asthma
• Tissue Adhesions
• Sclerosis
• Nasal Polyps
• Tuberous Sclerosis
• Chronic Sinusitis

Interacting Proteins

• CCL13
• CCL17
• CCL21
• CCL28
• CCL5

• CXCL10
• CXCL11
• CXCL12
• CXCL14
• CXCL9

• PF4
• XCL1

Pathways

• Pathogenesis
• Chemotaxis
• Secretion
• Immune Response
• Angiogenesis
• Eosinophil Migration
• Localization
• Cell Growth
• Cell Migration
• Reverse Transcription
• Cell Differentiation
• Exocytosis
• Cell Proliferation

• Cell Adhesion
• Superoxide Anion Generation
• Sensitization
• Chemokine Secretion
• Epithelial Cell Differentiation
• Eosinophil Activation
• Eosinophil Extravasation

PTMs

• Phosphorylation
• Citrullination

• Deacetylation
• Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCL26

Best Uses Of The CCL26 Marker From Boster Bio

Anti-C-C motif Chemokine 26 (CCL26), is a powerful tool used to study the effects of cancer cells. Boster Bio stocks the primary antibody. It is highly specific. Boster antibodies are extensively known and highly cited in the research community. They have been validated by Western Blotting and Immunohistochemistry as well as ELISA. This article describes the many applications of CCL26 in cancer research.

Anti-C-C motif Chemokine 26 CCL26 Signer

The Chemokine system is responsible for immune cell positioning and migration. It is also necessary for the treatment of acute inflammation and homeostasis. These chemokines can be found in lymphoid and non-lymphoid tissues. Boster Bio has developed a marker called Anti-C–C motif-chemokine 26 CCL26 to determine the amount of this important molecule.

Anti-C-C motif Chemokines possess a special binding affinity for their C–C motifs. This allows them to identify and neutralize complex molecules in a sophisticated way. Anti-C-C motif chemokines (CCLs) are created by immune cells to regulate the immune system of the body. The C-C motif is a well-known structure within human chemokines. Six cysteine residues are conserved in the C-C motif. CCL25 is a protein that is expressed in immune cells, particularly T cells and B cells. It is also associated with allergies and inflammatory conditions.

It is widely believed that the C-C motif chemokine 26(CCL26), regulates the activity of other immune cells in our bodies which includes macrophages. This hypothesis is not supported by the evidence. In addition to anti-CCC-C motif chemokines C-C motif chemokines, and heat-shock proteins play a role in the pathogenesis of interstitial lung disease.

This research found that the anti-C-C anti-C-C chemokine CCL26 marker is effective in identifying anti-CCC chemokine molecules. It is a useful instrument for studying cell responses and identifying the CCR3 ligand. These experiments revealed that CCR3 as well as CCL25 could play a part in the pathogenesis of Neoplasms eosinophilic.

The CCL26 gene is a regulator chemical that regulates the production of other chemokines. This receptor is located within the nucleus human epithelial cells of the bronchial bronchial. GSDMB-1 is an anti-C C motif chemokine chemokine receptor has been extensively investigated.

Clinical applications

The CCL26 marker is an important cell cytokine which regulates the inflammatory response in the body. It encourages eosinophils to chemotaxis and recruitment to inflammation foci. In the brain, CCL26 promotes the degranulation and release of cytotoxic substances by eosinophils. Thus, AIS is linked with the greater expression of CCL26.

CCL26 has been demonstrated to reduce the number of CD4+CD25+FOXP3+ Tregs among patients suffering from AIS. It also regulates the production of inflammation factors in PBMCs. The targeting of CCL26 by using an anti- or STAT5 inhibitor could be a new therapeutic approach to AIS. It is possible to investigate CCL26's role within the STAT5 pathway or a combination of the two.

Serpinb10 was also found to decrease asthma-related inflammation and hyperresponsiveness in mice. After sensitization, pulmonary resistance could be determined. After OVA challenge, inflammatory scores were calculated. Additionally, the counts of cells were determined. Quantitative PCR was employed to determine levels of transcripts. The data presented are the results of at least three independent tests. This study was conducted in a variety of animal models, including humans with asthma.

The CCL26 marker is currently extensively utilized in animal models to test airway eosinophilic inflammatory. This protein is highly expressed in the airways of mice suffering with OVA. This gene regulates the immune response of regulatory cells. It also contributes to human asthma's airway eosinophilic inflammation. In humans, CCL26 is an essential part of immune regulation.

Asthma is a diverse disease that has a variety of mechanisms. It is essential to identify biomarkers specific for phenotypes for the implementation of precision medicine. The CCL26 marker can be assessed using flow cytometry along with other methods. It can also predict the therapeutic response to targeted treatments. It can also help patients with AIS by predicting the emergence and type of Treg.

Immunoblotting

The CCL26 marker from Boster Bio can help you complete this test with ease. This marker is highly specific to detect CCL26 in cells. This method is based on the principle that antibodies are able to bind to antigens inside cells. As with other methods of immunoblotting requires some amount of sample preparation and optimization. Boster's Immunoblotting using CCL26 marker comes with a detailed guide that will guide you through the process step-by step and provide useful tips to determine the best results.

To carry out this assay, the first step was to create commercially available cloned CCL26 gene from the NIAID/NIID. The CCL26 marker was then added to Boster Bio pSBbiBla vector. This requires two independent HTS experiments.

The second step is to determine the protein in the membrane after the primary antibody has been used. The secondary antibody is used to detect CCL26 protein on the membrane. According to the instructions of the manufacturer the primary antibody must first be diluted in Antibody Diluent Buffer. A typical secondary antibody should be reduced to 1,000,000 before it is applied to the membrane. After the first step, the membrane should be rinsed three times with TBS Wash Buffer, followed by three further times with TBS Blocking Buffer. The membrane should be placed on a clear preservative film. In the end, transparent glass should be used to eliminate air bubbles.

The CCL26 marker from Boster Bio is highly specific for the detection of CCL26 in cells. This antibody is made from an amino acid precursor which are vital for the production of collagen. The secondary antibody is utilized to decrease non-specific binding and increase the accuracy of the analysis. This CCL26 marker can also be utilized in other applications. Once the primary antibody is been bound to the antigen it will be visible on the membrane.

However, if CCL26 is a target for a specific antibody it will be detected through immunoblotting. In this regard, the CCL26 marker from Boster Bio is an antibody that is fluorescent. This means that it will help differentiate between two types of cancer-related antibodies. It is particularly useful for cancer research since it allows you to observe the presence of CCL26 in cancer cells.

Alternatives to treat

CCL26, the gene responsible for eosinophilic esophagitis is a marker. This condition is becoming more prevalent in humans , and is largely due to food allergies. Studies have implicated the T helper 2 pathway which includes interleukins 5 as well as 13, in the onset of the disease. Currently, the best available treatment options are to avoid eating a diet full of allergens, as well being anti-inflammatory medications. Recent genome studies have revealed the presence of polymorphisms within the TSLP gene.

Despite the insufficient knowledge about CCL26's involvement in cancer, it has been linked to poor prognosis. It is interesting that tumors that have high levels of CCL26 have been associated with a lower prognosis than those with low levels. The reasons behind this connection aren't completely understood, however, elevated CCL26 levels may be a signal of an uninhibited Antigen-Presenting Cell (APC) lining the tumor.