Anti-Fatty aldehyde dehydrogenase Aldh3A2 Antibody

Product Name

Anti-Fatty aldehyde dehydrogenase Aldh3A2 Antibody

View all ALDH3A2 Antibodies

SKU/Catalog Number

A05079

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Fatty aldehyde dehydrogenase Aldh3A2 Antibody (Catalog # A05079). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

Aldh3A2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-Fatty aldehyde dehydrogenase Aldh3A2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05079)

Host

Rabbit

Contents

Aldh3A2 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Aldh3A2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human Aldh3A2. The immunogen is located within the last 50 amino acids of Aldh3A2.

Cross-reactivity

At least four isoforms of Aldh3A2 are known to exist. This antibody is predicted to have no cross-reactivity to Aldh3A1.

Reactive Species

A05079 is reactive to ALDH3A2 in Human, Mouse

Observed Molecular Weight

68 kDa

Calculated molecular weight

54.8 kDa

Background of ALDH3A2

Aldh3A2 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh3A2 catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Mutations in the Aldh3A2 gene cause Sjogren-Larrson syndrome, an inherited neurocutaneous disorder. Patients with this disorder display ichthyosis, mental retardation and spastic diplegia. The pathogenesis of the cutaneous and neurological symptoms is thought to result from abnormal lipid accumulation in the membranes of skin and brain, the formation of aldehyde Schiff base adducts with amine-containing lipids or proteins, or defective eicosanoid metabolism.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A05079 is guaranteed for ELISA, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Aldh3A2 antibody can be used for detection of Aldh3A2 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information ALDH3A2

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