Product Info Summary
SKU: | A04115 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | WB |
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Product info
Product Name
Anti-Gads (N158) GRAP2 Antibody
SKU/Catalog Number
A04115
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Gads (N158) GRAP2 Antibody catalog # A04115. Tested in WB applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Gads (N158) GRAP2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04115)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human MST-3
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A04115 is reactive to GRAP2 in Human, Mouse, Rat
Applications
A04115 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
37.909kDa
Background of GRAP2
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
Schinkmann K., J. Biol. Chem. 272:28695-28703(1997).
Zhou T.-H., J. Biol. Chem. 275:2513-2519(2000).
Dunham A., Nature 428:522-528(2004).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:1000
Validation Images & Assay Conditions
There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.
Protein Target Info & Infographic
Gene/Protein Information For GRAP2 (Source: Uniprot.org, NCBI)
Gene Name
GRAP2
Full Name
GRB2-related adapter protein 2
Weight
37.909kDa
Superfamily
GRB2/sem-5/DRK family
Alternative Names
Adapter protein GRID; GADS; GADSSH3-SH2-SH3 adapter Mona; GRAP2; GRB2L; GRB-2-like protein; GRB2-related adapter protein 2; GRB2-related adaptor protein 2; GRB2-related protein with insert domain; GRBLG; GRBLGGRAP-2; GRBX; Grf40 adapter protein; Grf40; grf-40; GRID; GRIDGRPL; Growth factor receptor-binding protein; growth factor receptor-bound protein 2-related adaptor protein 2; GRPL; Hematopoietic cell-associated adapter protein GrpL; hematopoietic cell-associated adaptor protein GRPL; Mona; P38; Protein GADS; SH3-SH2-SH3 adaptor molecule GRAP2 GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38 GRB2 related adaptor protein 2 GRB2-related adapter protein 2|GRB-2-like protein|GRB2-related protein with insert domain|SH3-SH2-SH3 adapter Mona|SH3-SH2-SH3 adaptor molecule|adapter protein GRID|grf-40|grf40 adapter protein|growth factor receptor-binding protein|growth factor receptor-bound protein 2-related adaptor protein 2|hematopoietic cell-associated adapter protein GrpL|hematopoietic cell-associated adaptor protein GRPL
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GRAP2, check out the GRAP2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GRAP2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Gads (N158) GRAP2 Antibody (A04115)
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No publications found for A04115
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