Anti-Galectin 1/LGALS1 Antibody
Rabbit IgG polyclonal antibody for Galectin 1(LGALS1) detection. Tested with WB, IHC-P in Human.
Anti-Galectin 1/LGALS1 Antibody Info At A Glance
|Product Name||Anti-Galectin 1/LGALS1 Antibody
See all Galectin-1 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for GALECTIN 1/LGALS1 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. GALECTIN 1/LGALS1 information: Molecular Weight: 14716 MW; Subcellular Localization: Secreted, extracellular space, extracellular matrix ; Tissue Specificity: Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.|
|Cite This Product||Anti-Galectin 1/LGALS1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1422)|
|Similar Products From
|Anti-Galectin 1/LGALS1 Antibody may replace the following items: sc 166617|sc 166618|sc 166619|sc 19276|sc 19277|sc 28248|sc 31793.|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human Galectin 1(119-135aa NYMAADGDFKIKCVAFD), different from the related rat and mouse sequences by one amino acid.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For LGALS1 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||3956|
|Species Of This Entry||Human|
|Alternative Names||Galectin-1|14 kDa laminin-binding protein; 14 kDa lectin; Beta-galactoside-binding lectin L-14-I; BHL; DKFZp686E23103; GAL1; gal-1; Galaptin; galectin 1; Galectin1; Galectin-1; GBP; HBL; HLBP14; HPL; L-14; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; lectin, galactoside-binding, soluble, 1; LGALS1; Putative MAPK-activating protein PM12; S-Lac lectin 1|
|Post Tranlational Modifications||Glycosylation; Phosphorylation; Cleavage; Methylation; Biotinylation|
|Subcellular Localization||Secreted, extracellular space, extracellular matrix.|
|Gene Location||22q13.1, on Chromasome 22, gene sequence: NC_000022.11 (37675636..37679802)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For LGALS1 (Source: Uniprot.org, NCBI)
|Protein Function||Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.|
|Tissue Specificity||Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.|
|Interacting Proteins||ALCAM; CD6; KDR; PTPRC|
|Related Diseases||Neoplasms; Malignant Neoplasms; Carcinoma; Tissue Adhesions; Neoplasm Metastasis; Malignant Paraganglionic Neoplasm; Neoplasm Invasiveness; Cell Invasion; Inflammation; Autoimmune Reaction; Malignant Squamous Cell Neoplasm; Tumor Progression; Autoimmune Diseases; Tumor Angiogenesis; Liver Carcinoma; Nervousness; Hyperplasia; Malignant Neoplasm Of Breast; Melanoma; Colorectal Cancer|
|Related Pathways||Immune Response; Cell Adhesion; Pathogenesis; Cell Death; Secretion; Cell Migration; Cell Differentiation; Cell Proliferation; Glycosylation; Cell Cycle; Localization; Cell Growth; Angiogenesis; Regeneration; Cytokine Secretion; Cell Activation; T Cell Activation; Cell Motility; Cell-cell Adhesion; Transport|
|Background||Galectin-1 is a protein that in humans is encoded by the LGALS1 gene. Galectins belong to a family of related beta-galactoside-binding lectins, also referred to as S-type or S-Lac lectins. Its gene is mapped to 22q12-q13. Galectin-1 was expressed in a subset of slowly dividing subventricular zone astrocytes, which included the neural stem cells. It has been considered as an autocrine negative growth factor that regulates cell proliferation.|
|Scientific References||PMID: 2719964 by Hirabayashi J., et al. Cloning and nucleotide sequence of a full-length cDNA for human 14 kDa beta-galactoside-binding lectin.|
PMID: 2910856 by Couraud P.-O., et al. Molecular cloning, characterization, and expression of a human 14-kDa lectin.
Our Boster Quality Guarantee for Anti-Galectin 1/LGALS1 Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: Recombinant Human Galeactin-1 Protein 10ng
Lane 2: Recombinant Human Galeactin-1 Protein 5ng
Lane 3: Recombinant Human Galeactin-1 Protein 2.5ng
IHC(P): Human Intestinal Cancer Tissue
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
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Note: sample size takes longer to process, average 5-7 days.
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