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Product Info Summary
| SKU: | A09415-1 |
|---|---|
| Size: | 100ul |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IHC, WB |
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Product info
Product Name
Anti-GNL3L Antibody
SKU/Catalog Number
A09415-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-GNL3L Antibody catalog # A09415-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-GNL3L Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09415-1)
Host
Rabbit
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human GNL3L
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A09415-1 is reactive to GNL3L in Human
Applications
A09415-1 is guaranteed for ELISA, IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
65.573kDa
Background of GNL3L
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
Florindo C.S., Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Devroe E., J. Biol. Chem. 279:24444-24451(2004).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
Validation Images & Assay Conditions
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Figure 1. Western blotting validation for Anti-GNL3L Antibody A09415-1
Western Blot (WB) analysis of specific cells using GNL3L polyclonal antibody.Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
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Figure 2. Western blotting validation for Anti-GNL3L Antibody A09415-1
Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
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Figure 3. Western blotting validation for Anti-GNL3L Antibody A09415-1
Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
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Figure 4. Western blotting validation for Anti-GNL3L Antibody A09415-1
Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
Protein Target Info & Infographic
Gene/Protein Information For GNL3L (Source: Uniprot.org, NCBI)
Gene Name
GNL3L
Full Name
Guanine nucleotide-binding protein-like 3-like protein
Weight
65.573kDa
Superfamily
TRAFAC class YlqF/YawG GTPase family
Alternative Names
EC 3.6.1; FLJ10613; guanine nucleotide binding protein-like 3 (nucleolar)-like; guanine nucleotide-binding protein-like 3-like protein; novel GTPase GNL3L GNL3B G protein nucleolar 3 like guanine nucleotide-binding protein-like 3-like protein|G protein nucleolar 3B|guanine nucleotide binding protein-like 3 (nucleolar)-like|novel GTPase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GNL3L, check out the GNL3L Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GNL3L: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-GNL3L Antibody (A09415-1)
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No publications found for A09415-1
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Customer Reviews
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