GNL3L Antibodies

AND GNL3L ELISA kits, GNL3L Proteins

Many biological assays use antibodies to detect GNL3L, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GNL3L in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GNL3L antibodies...

We validate the specificity of these antibodies to GNL3L by testing them on tissues known to express GNL3L positively and negatively. Browse below to find the GNL3L antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for GNL3L? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the GNL3L IHC Guide

GNL3L Infographic by Boster Bio

All GNL3L Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-GNL3L Antibody

Western Blot analysis of HT29 cells using GNL3L Polyclonal Antibody diluted at 1:2000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit

Western blot analysis of lysates from 293, HeLa, and HT-29 cells, using GNL3L Antibody

Human, Mouse, Rat, Cat

ELISA, IF, IHC, WB

$399
Cat # A09415
100μl

GNL3L (NM_019067) Human Over-expression Lysate

Human

$628
Cat # LS054552
20 µg, 100 µg

GNL3L Overview

Facts about Guanine nucleotide-binding protein-like 3-like protein.

GNL3L 3D structure. Source: alphafold

Guanine nucleotide-binding protein-like 3-like protein (GNL3L)

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and thus proteasomal degradation.

Does so by interfering with TERF1-binding into FBXO4 E3 ubiquitin-protein ligase. By minding TRF1 protein during mitosis, promotes metaphase-to-anaphase transition.

Gene Information

Human
Gene Name:	GNL3L
Uniprot:	Q9NVN8
Entrez:	54552

Family

Belongs to:

TRAFAC class YlqF/YawG GTPase family

Alternative Names

EC 3.6.1; FLJ10613; guanine nucleotide binding protein-like 3 (nucleolar)-like; guanine nucleotide-binding protein-like 3-like protein; novel GTPase

Molecular Weight

Mass (kDA):
65.573 kDA

Genomic Context


Human

Location:	Xp11.22
Sequence:	X; NC_000023.11 (54530219..54567289)

Subcellular Localizations

Nucleus, nucleolus.

Diseases

Neoplasms
Telomere Shortening
Neoplasm Metastasis
Cell Transformation, Neoplastic
Malignant Neoplasms
Leukemia
Acute Promyelocytic Leukemia
Mammary Neoplasms
Gastrointestinal Neoplasms

Myeloid Leukemia, Chronic
Behavioral Tic
Carcinoma

Interacting Proteins

ALAS1
LDOC1
LZTS2
MDM2
ROPN1

Pathways

Localization
Cell Cycle
Mitosis
Transport
Senescence
Telomere Binding
Regeneration
Tissue Regeneration
Cellular Senescence

Cell Growth
Nuclear Export
Nuclear Transport

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GNL3L

References

PMID: 16251348 by Du X., et al. The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA.

PMID: 17034816 by Rao M.R.K.S., et al. A novel lysine-rich domain and GTP binding motifs regulate the nucleolar retention of human guanine nucleotide binding protein, GNL3L.