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Product Info Summary
| SKU: | A12994-1 |
|---|---|
| Size: | 100ul |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | IF, ICC, WB |
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Product info
Product Name
Anti-HAUS8 Antibody
SKU/Catalog Number
A12994-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-HAUS8 Antibody catalog # A12994-1. Tested in WB,ICC/IF applications. This antibody reacts with Human,Mouse.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-HAUS8 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A12994-1)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
Antiserum
Immunogen
Anti-HICE1 was prepared from whole rabbit serum produced by repeated immunizations with a recombinant full length Hice1 protein.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A12994-1 is reactive to Haus8 in Human, Mouse
Applications
A12994-1 is guaranteed for IF, ICC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
41.653kDa
Background of Haus8
This antibody is suitable for Cancer, Immunology and Nuclear Signaling research. Hice1 contributes to the mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Normal bipolar spindle formation is critical for accurate chromosome segregation and proper mitotic progression. Failure in this event leads to spindle checkpoint activation and chromosome missegregation that ultimately leads to aneuploidy. Hice1 binds to microtubules directly, and promotes spindle integrity and chromosome stability. Hice1 has also shown to play an important role in targeting the gamma TuRC complex to the mitotic spindle, a step that appears to be required for spindle-mediated microtubule generation and normal chromosome segregation. The HAUS augmin-like complex's interaction with microtubules is strong during mitosis, while it is weak or absent during interphase. During interphase, it is primarily cytoplasmic, associating with centrosomes and with the mitotic spindles, preferentially at the spindle pole vicinity. During anaphase and telophase, it additionally associates with the spindle midzone and midbody, respectively. Further characterization of the function of Hice1 will likely be important for better understanding the mechanism of normal mitotic progression and high fidelity chromosome segregation.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:2000
ICC/IF: 1:50-1:200
Validation Images & Assay Conditions
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Figure 1. Western blotting validation for Anti-HAUS8 Antibody A12994-1
Western blot analysis of extracts of various cell linesProtein Target Info & Infographic
Gene/Protein Information For Haus8 (Source: Uniprot.org, NCBI)
Gene Name
Haus8
Full Name
HAUS augmin-like complex subunit 8
Weight
41.653kDa
Superfamily
HAUS8 family
Alternative Names
DGT4; HAUS Augmin Like Complex Subunit 8; HEC1/NDC80 interacting, centrosome associated 1; HEC1/NDC80-Interacting Centrosome-Associated Protein 1; Hec1-Interacting And Centrosome-Associated 1; HICE1; NY-SAR-48; Sarcoma Antigen NY-SAR-48
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Haus8, check out the Haus8 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Haus8: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-HAUS8 Antibody (A12994-1)
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